MMG-11 quarterhydrate

Cat. No.: HY-112146A Purity: 99.09%: FAQs
Data Sheet SDS COA Handling Instructions

MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC₅₀s of 1.7 µM for Pam₃CSK₄-induced hTLR2/1 and 5.7 µM for Pam₂CSK₄-induced hTLR2/6 responses.

For research use only. We do not sell to patients.

MMG-11 quarterhydrate Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 245	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of MMG-11 quarterhydrate:

MMG-11 In-stock

2 Publications Citing Use of MCE MMG-11 quarterhydrate

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

TLR2

In Vitro

MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 µM) shows no cytotoxic effects up to 100 µM in peripheral blood mononuclear cells (PBMCs)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	PBMCs
Concentration:	0.01, 1, 10, 100 µM
Incubation Time:
Result:	Showed no cytotoxic effects up to 100 µM.

Molecular Weight

310.78

Appearance

Solid

Formula

C₁₅H₁₄O₇.1/4H₂O

SMILES

OC1=C(O)C(O)=C(C(CC2=CC=C(C(OCC)=O)O2)=O)C=C1.[1/4].O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (321.77 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2177 mL	16.0886 mL	32.1771 mL
5 mM	0.6435 mL	3.2177 mL	6.4354 mL
10 mM	0.3218 mL	1.6089 mL	3.2177 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.04 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.04 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (6.69 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.09%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (250 KB) HNMR (238 KB) LCMS (244 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160. [Content Brief]