1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. CAY10614

CAY10614 

Cat. No.: HY-135042
Handling Instructions

CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model.

For research use only. We do not sell to patients.

CAY10614 Chemical Structure

CAY10614 Chemical Structure

CAS No. : 1202208-36-3

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Description

CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model[1][2].

IC50 & Target[1]

TLR4

1.675 μM (IC50, in HEK293 cells)

In Vitro

CAY10614 (compound 7) (1-10 μM) inhibits the lipid A-induced increase of phosphatase activity in a concentration-dependent manner in HEK293 cells[1].
CAY10614 (0.5 μM) inhibits the increase of [Ca2+]cyt induced by LPS in >18 days in vitro (DIV) neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CAY10614 (compound 7) (10 mg/kg; i.p. 30 min before the LPS) significantly improves survival of mice given intraperitoneal LPS (20 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male mice (9 weeks) were i.p. injected with 20 mg/kg LPS[1]
Dosage: 10 mg/kg
Administration: I.p. 30 min before the LPS
Result: Increased the survival rate of mice from 0% to 67%.
Molecular Weight

755.98

Formula

C₄₂H₇₈INO₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CAY10614
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HY-135042
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