1202208-36-3
1202208-36-3
Chemical Structure
CAY10614
- CAS. Nr.: 1202208-36-3
- Formula:C42H78INO2
- Molecular Weight:755.98
IUPAC Name: N-(3,4-bis(tetradecyloxy)benzyl)-N,N-dimethylcyclopentanaminium iodide
InChIKey: UXOPVNPWTUWUEA-UHFFFAOYSA-M
SMILES: CCCCCCCCCCCCCCOC1=CC=C(C[N+](C)(C2CCCC2)C)C=C1OCCCCCCCCCCCCCC.[I-]
Biological Activity: CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model[1][2].
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CAY10614 | 98.87% | CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. CAY10614 can improve survival of mice in lethal endotoxin shock model. | ||||||||||||||||||||
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References
- [1]. Piazza M, et, al. Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization. J Med Chem. 2009 Feb 26;52(4):1209-13. [Content Brief]
- [2]. Rodríguez MC, et, al. Aging and amyloid β oligomers enhance TLR4 expression, LPS-induced Ca 2+ responses, and neuron cell death in cultured rat hippocampal neurons. J Neuroinflammation. 2017 Jan 31;14(1):24. [Content Brief]
