Trypanothione synthetase-IN-4
Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis.
For research use only. We do not sell to patients.
- CAS No.: 3033799-62-8
- Formula: C29H52INO2
- Molecular Weight:573.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Leishmania |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
21.3 μM
Compound: 5
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Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis
Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis
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[PMID: 36075146] |
Trypanothione synthetase-IN-4 (15 μM) has activity against LiTryS for three substrates (ATP, GSH and Spd) with IC50 values of 7.3 μM, 7.8 μM and 5.5 μM, respectively[1].
Trypanothione synthetase-IN-4 (25 μM, 24 h) has antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum[1].
Trypanothione synthetase-IN-4 (25 μM, 72 h) is active against intracellular amastigotes (EC50=0.6 μM) and has a high selectivity index of 35.5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 (human hepatoma cell line)
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Concentration:25 μM
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Incubation Time:72 h
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Result:Showed antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum.
Chemical Information
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CAS No. 3033799-62-8
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Molecular Weight 573.63
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Formula C29H52INO2
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SMILES
C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trypanothione synthetase-IN-4 Related Classifications
HY-151149 Related Classifications
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