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  4. Trypanothione synthetase-IN-4

Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis.

For research use only. We do not sell to patients.

Trypanothione synthetase-IN-4

Trypanothione synthetase-IN-4 Chemical Structure

CAS No. : 3033799-62-8

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Trypanothione synthetase-IN-4 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].

IC50 & Target

Leishmania

 

Cellular Effect
Cell Line Type Value Description References
HepG2 CC50
21.3 μM
Compound: 5
Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis
Cytotoxicity against human HepG2 cells assessed as reduction in cell proliferation measured after 72 hrs by crystal violet staining based analysis
[PMID: 36075146]
In Vitro

Trypanothione synthetase-IN-4 (15 μM) has activity against LiTryS for three substrates (ATP, GSH and Spd) with IC50 values of 7.3 μM, 7.8 μM and 5.5 μM, respectively[1].
Trypanothione synthetase-IN-4 (25 μM, 24 h) has antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum[1].
Trypanothione synthetase-IN-4 (25 μM, 72 h) is active against intracellular amastigotes (EC50=0.6 μM) and has a high selectivity index of 35.5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trypanothione synthetase-IN-4 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 (human hepatoma cell line)
Concentration: 25 μM
Incubation Time: 72 h
Result: Showed antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum.
Molecular Weight

573.63

Formula

C29H52INO2
CAS No.
SMILES

C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trypanothione synthetase-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-43033799-62-8ParasiteL. infantumtrypanothione synthetase (TryS)polyamineanti-leishmanicidalparasitesInhibitorinhibitorinhibit

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