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  4. Trypanothione synthetase-IN-4

Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis.

For research use only. We do not sell to patients.

Trypanothione synthetase-IN-4 Chemical Structure

Trypanothione synthetase-IN-4 Chemical Structure

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Trypanothione synthetase-IN-4 Related Antibodies

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Description

Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].

IC50 & Target

IC50 against LiTryS: 7.3 μM (ATP); 7.8 μM (GSH) and 5.5 μM (Spd)[1].
EC50: 0.4 μM (L. infantum); 0.6 μM (against intracellular amastigotes)[1].
In Vitro

Trypanothione synthetase-IN-4 (15 μM) has activity against LiTryS for three substrates (ATP, GSH and Spd) with IC50 values of 7.3 μM, 7.8 μM and 5.5 μM, respectively[1].
Trypanothione synthetase-IN-4 (25 μM, 24 h) has antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum[1].
Trypanothione synthetase-IN-4 (25 μM, 72 h) is active against intracellular amastigotes (EC50=0.6 μM) and has a high selectivity index of 35.5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trypanothione synthetase-IN-4 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 (human hepatoma cell line)
Concentration: 25 μM
Incubation Time: 72 h
Result: Showed antileishmanial activity with an EC50 value of 0.4 μM in axenic amastigotes of L. infantum.
Molecular Weight

573.63

Formula

C29H52INO2
SMILES

C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trypanothione synthetase-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-4ParasiteL. infantumtrypanothione synthetase (TryS)polyamineanti-leishmanicidalparasitesInhibitorinhibitorinhibit

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