2. Signaling Pathways
  3. Anti-infection
  4. Parasite
  5. Toxoplasma Isoform

Toxoplasma

Toxoplasma gondii is an obligate, intracellular protozoan parasite in the phylum Apicomplexa that is infectious to a wide variety of animals. Approximately 25 to 30% of the world’s population is thought to be infected with T. gondii .The life cycle of T. gondii involves three different forms: rapidly dividing, invasive tachyzoites; slowly dividing cyst bradyzoites; and an environmentally hardy oocyst containing infectious sporozoites. Classically, the T. gondii life cycle alternates between a definitive felid (cat) host and an intermediate host. Cats become infected when they ingest tissue contaminated with T. gondii cysts. These cysts infect enterocytes and undergo sexual reproduction to form the oocysts. Oocysts are excreted in the feces into the environment and internally sporulate, becoming infectious within 2 to 3 days of being released. Infection of the intermediate host (e.g., rodents, herbivores, humans) typically occurs through ingestion of oocysts in contaminated food or water, although humans and other animals can also become infected by eating raw or undercooked meat containing T. gondii cysts. Following ingestion, parasites penetrate the intestinal lining and differentiate into tachyzoites, which can invade virtually any host cell, replicate, and disseminate throughout the body. For approximately 90% of otherwise healthy individuals, infection with T. gondii is entirely asymptomatic. The remaining 10% of patients typically experience self-limiting, nonspecific symptoms, including fever and lymphadenitis, which may last for several weeks and mimic other infectious diseases.

Toxoplasma Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-116090
    Conoidin A
    		Inhibitor 98.03%
    Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 µM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.
  • HY-10373
    Trimetrexate
    		Inhibitor 99.22%
    Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.
  • HY-B0273
    Sulfadiazine
    		Inhibitor 99.88%
    Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research.
  • HY-12724A
    Guanabenz hydrochloride
    		Inhibitor 99.95%
    Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist. Guanabenz hydrochloride has antihypertensive effect and antiparasitic activity. Guanabenz hydrochloride interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz hydrochloride also is used for the research of high blood pressure.
  • HY-101525
    MBP146-78
    		Inhibitor 98.47%
    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
  • HY-100593
    Spiramycin
    		Inhibitor 99.19%
    Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached.
  • HY-117015
    Purfalcamine
    		Inhibitor 99.44%
    Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage.
  • HY-N5060
    Estragole
    		98.58%
    Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability. Estragole displays anti-toxoplasma activity.
  • HY-N9320
    13,21-Dihydroeurycomanone
    		Inhibitor 98.11%
    13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii.
  • HY-115972
    Anti-Trypanosoma cruzi agent-2
    		Inhibitor
    Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC50 = 0.51 µM) and INC-5 epimastigote form (IC50 = 3.06 µM), posseses anti-T. gondii activity.
  • HY-10373B
    Trimetrexate isethionate
    		Inhibitor
    Trimetrexate (CI-898) isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.
  • HY-10373A
    Trimetrexate trihydrochloride
    		Inhibitor
    Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.
  • HY-147003
    MMV687807
    		Inhibitor
    MMV687807 is an anthelmintic agent which has a good activity against Toxoplasma gondii (T. gondii) with an IC50 value of 0.15 μM and a CC50 value of 1.69 μM.
  • HY-B0273S1
    Sulfadiazine-13C6
    		Inhibitor
    Sulfadiazine-13C6 is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].
  • HY-12724
    Guanabenz
    		Inhibitor
    Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure.
  • HY-115971
    Anti-Trypanosoma cruzi agent-1
    		Inhibitor
    Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T. gondii activity.
  • HY-N8707
    Homobutein
    		Inhibitor
    Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation.