1. Signaling Pathways
  2. Anti-infection
  3. Parasite
  4. Toxoplasma Isoform

Toxoplasma

Toxoplasma gondii is an obligate, intracellular protozoan parasite in the phylum Apicomplexa that is infectious to a wide variety of animals. Approximately 25 to 30% of the world’s population is thought to be infected with T. gondii .The life cycle of T. gondii involves three different forms: rapidly dividing, invasive tachyzoites; slowly dividing cyst bradyzoites; and an environmentally hardy oocyst containing infectious sporozoites. Classically, the T. gondii life cycle alternates between a definitive felid (cat) host and an intermediate host. Cats become infected when they ingest tissue contaminated with T. gondii cysts. These cysts infect enterocytes and undergo sexual reproduction to form the oocysts. Oocysts are excreted in the feces into the environment and internally sporulate, becoming infectious within 2 to 3 days of being released. Infection of the intermediate host (e.g., rodents, herbivores, humans) typically occurs through ingestion of oocysts in contaminated food or water, although humans and other animals can also become infected by eating raw or undercooked meat containing T. gondii cysts. Following ingestion, parasites penetrate the intestinal lining and differentiate into tachyzoites, which can invade virtually any host cell, replicate, and disseminate throughout the body. For approximately 90% of otherwise healthy individuals, infection with T. gondii is entirely asymptomatic. The remaining 10% of patients typically experience self-limiting, nonspecific symptoms, including fever and lymphadenitis, which may last for several weeks and mimic other infectious diseases.

Toxoplasma Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-10373
    Trimetrexate
    Inhibitor 99.45%
    Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR.
  • HY-116090
    Conoidin A
    Inhibitor 98.03%
    Conoidin A is a cell permeable inhibitor of T.
  • HY-101525
    MBP146-78
    Inhibitor 98.47%
    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.
  • HY-B0273
    Sulfadiazine
    Inhibitor 99.86%
    Sulfadiazine is a sulfonamide antibiotic with antimalarial activity.
  • HY-100593
    Spiramycin
    Inhibitor 99.19%
    Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect.
  • HY-12724A
    Guanabenz hydrochloride
    Inhibitor
    Guanabenz hydrochloride is an orally active α-2-adrenoceptor agonist.
  • HY-10373B
    Trimetrexate isethionate
    Inhibitor
    Trimetrexate (CI-898) isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR.
  • HY-10373A
    Trimetrexate trihydrochloride
    Inhibitor
    Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR.
  • HY-117015
    Purfalcamine
    Inhibitor 99.71%
    Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM.
  • HY-N9320
    13,21-Dihydroeurycomanone
    Inhibitor 98.11%
    13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii.
  • HY-115972
    Anti-Trypanosoma cruzi agent-2
    Inhibitor
    Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC50 = 0.51 µM) and INC-5 epimastigote form (IC50 = 3.06 µM), posseses anti-T.
  • HY-147003
    MMV687807
    Inhibitor
    MMV687807 is an anthelmintic agent which has a good activity against Toxoplasma gondii (T.
  • HY-B0273S1
    Sulfadiazine-13C6
    Inhibitor
    Sulfadiazine-13C6 is a labeled Sulfadiazine (HY-B0273).
  • HY-12724
    Guanabenz
    Inhibitor
    Guanabenz is an orally active α-2-adrenoceptor agonist.
  • HY-115971
    Anti-Trypanosoma cruzi agent-1
    Inhibitor
    Anti-Trypanosoma cruzi agent-1 (Compd E5) posseses anti-T.
  • HY-B0273A
    Sulfadiazine sodium
    Inhibitor ≥98.0%
    Sulfadiazine sodium is a sulfonamide antibiotic with antimalarial activity.
  • HY-N8707
    Homobutein
    Inhibitor
    Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively.