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  3. Conoidin A

Conoidin A 

Cat. No.: HY-116090 Purity: 98.03%
Handling Instructions

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 µM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.

For research use only. We do not sell to patients.

Conoidin A Chemical Structure

Conoidin A Chemical Structure

CAS No. : 18080-67-6

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 100 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 µM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII)[1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3].

IC50 & Target

IC50: 23 µM (T. gondii enzyme peroxiredoxin II (TgPrxII))[1]

In Vitro

Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and signal transduction. And the changes in PrxII expression are associated with a variety of human diseases, including cancer[1].
Conoidin A binds to the peroxidatic cysteine of TgPrxII, inhibiting its enzymatic activity in vitro. Conoidin A also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV with similar efficiency. But it is ineffective to mitochondrial hPrxIII[2].
Conoidin A (5 µM) can inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Conoidin A (intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation. Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishs the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat myocardial I/R model[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; for three successive days before MI/R injury
Result: Significantly reversed the antioxidative effect of Luteolin.
Impaired the protective effects of luteolin.
Molecular Weight

347.99

Formula

C₁₀H₈Br₂N₂O₂

CAS No.
SMILES

[O-][N+]1=C(C(CBr)=[N+](C2=C1C=CC=C2)[O-])CBr

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (41.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8736 mL 14.3682 mL 28.7365 mL
5 mM 0.5747 mL 2.8736 mL 5.7473 mL
10 mM 0.2874 mL 1.4368 mL 2.8736 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (4.11 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Conoidin AParasitehyperperoxidationantioxidantneuroprotectiveischaemicheart diseaseantioxidativePeroxiredoxin IIInhibitorinhibitorinhibit

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Conoidin A
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