2. NF-κB Apoptosis Autophagy Metabolic Enzyme/Protease
  3. Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite
  4. Luteolin

Luteolin  (Synonyms: Luteoline; Luteolol; Digitoflavone)

Cat. No.: HY-N0162 Purity: 99.01%
COA Handling Instructions

Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells.

For research use only. We do not sell to patients.

Luteolin Chemical Structure

Luteolin Chemical Structure

CAS No. : 491-70-3

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10 mM * 1 mL in DMSO USD 55 In-stock
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Based on 29 publication(s) in Google Scholar

Other Forms of Luteolin:

Luteolin Related Antibodies

Top Publications Citing Use of Products

    Luteolin purchased from MCE. Usage Cited in: Front Pharmacol. 2018 Jun 13;9:620.  [Abstract]

    Effects of Luteolin on the level of CTSD and p-CDK2 in HK-2 cells. The western blotting results of CTSD and p-CDK2 in the NaOx-stimulated HK-2 cells treated by Luteolin.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2][3].

    In Vitro

    Luteolin (0-160 µM; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner[1].
    Luteolin (20-80 µM; 24 hours; NCI-H460 cells) treatment causes an accumulation of cells in the S phase[1].
    Luteolin (320-580 µM; 48 hours; NCI-H460 cells) treatment induces apoptosis[1].
    Luteolin (20-80 µM; 24 hours; NCI-H460 cells) treatment increases the protein expression levels of apoptotic regulatory proteins, including the Bax/Bcl-2 ratio, in a concentration-dependent manner, however, only 80 µM Luteolin inhibits the expression of Bad. Luteolin also decreases the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Luteolin Related Antibodies

    Cell Viability Assay[1]

    Cell Line: NCI-H460 cells
    Concentration: 0 µM, 20 µM, 40 µM, 80 µM and 160 µM
    Incubation Time: 24 hours
    Result: Inhibited the viability of NCI-H460 cells in a concentration-dependent manner.

    Cell Cycle Analysis[1]

    Cell Line: NCI-H460 cells
    Concentration: 20 µM, 40 µM, 80 µM
    Incubation Time: 24 hours
    Result: Induced cell cycle arrest in the S phase.

    Apoptosis Analysis[1]

    Cell Line: NCI-H460 cells
    Concentration: 320 µM, 440 µM, 580 µM
    Incubation Time: 48 hours
    Result: Apoptotic fraction was markedly increased.

    Western Blot Analysis[1]

    Cell Line: NCI-H460 cells
    Concentration: 20 µM, 40 µM, 80 µM
    Incubation Time: 24 hours
    Result: Increased the protein expression levels of apoptotic regulatory proteins and decreased the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner.
    In Vivo

    Luteolin (10-100 mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult male Wistar rats (200-220 g)[2]
    Dosage: 10 mg/kg, 25 mg/kg, 50 mg/kg or 100 mg/kg
    Administration: Oral gavage; daily; for 12 weeks
    Result: Significantly reduced ALT and AST activity and reduced levels of bilirubin, hyaluronic acid and malondialdehyde. Shows an antioxidant activity such as a significant increase in reduced glutathione. IFN-γ, TNF-α, IL-1α and IL-18 levels decreased significantly.
    Clinical Trial
    Molecular Weight

    286.24

    Appearance

    Solid

    Formula

    C15H10O6
    CAS No.
    SMILES

    O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (349.36 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4936 mL 17.4679 mL 34.9357 mL
    5 mM 0.6987 mL 3.4936 mL 6.9871 mL
    10 mM 0.3494 mL 1.7468 mL 3.4936 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  50% PEG300    50% saline

      Solubility: 20 mg/mL (69.87 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.01%

    COA (248 KB) HNMR (298 KB) LCMS (95 KB)

    Handling Instructions (2659 KB)
    References
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    Luteolin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Keywords:

    Luteolin491-70-3Luteoline Luteolol DigitoflavoneKeap1-Nrf2ApoptosisAutophagyEndogenous MetaboliteInhibitorinhibitorinhibit

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