1. Signaling Pathways
  2. Anti-infection
  3. Parasite
  4. Leishmania Isoform

Leishmania

Members of the Leishmania genus are obligate, intracellular vector-borne protozoa which can cause a wide spectrum of disease, ranging from asymptomatic infection to diffuse or localized cutaneous leishmaniasis (CL), visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL). Leishmania spp. are members of the order Kinetoplastida due to the presence of a kinetoplast. Leishmaniasis remains a neglected tropical disease, with approximately 310 million individuals at risk for contracting the infection, 12 million people currently infected, and an annual incidence of 2 million new infections. There are two major forms of the parasite, the extracellular promastigote found in the sand fly and the intracellular amastigote found in vertebrate hosts. While the classic mode of Leishmania transmission is through the bite of an infected sand fly, infection through contaminated needles shared among intravenous drug users, blood transfusion, organ transplantation and vertical transmission have also been documented, albeit rarely.

Leishmania Related Products (24):

Cat. No. Product Name Effect Purity
  • HY-19719
    Miransertib
    Inhibitor 99.33%
    Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
  • HY-B0537B
    Pentamidine isethionate
    Inhibitor 99.82%
    Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics.
  • HY-103353
    SID 26681509
    Inhibitor 98.26%
    SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM.
  • HY-N2575
    Hypocrellin A
    Inhibitor 98.84%
    Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities.
  • HY-N6961
    Lapachol
    Inhibitor 98.67%
    Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae).
  • HY-101397
    Allopurinol riboside
    Inhibitor 99.04%
    Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.
  • HY-N1453
    Hypocrellin B
    Inhibitor 98.12%
    Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer.
  • HY-N0769
    Isopimpinellin
    Inhibitor 99.69%
    Isopimpinellin, an orally active compound isolated from Glomerella cingulata.
  • HY-N0397
    Harpagide
    Inhibitor 99.72%
    Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.
  • HY-U00128
    PPA-904
    Inhibitor 99.31%
    PPA-904 is a specific phenothiazine photosensitizer in photodynamic therapy (PDT) research, especially topical application for cutaneous leishmaniasis in vivo.
  • HY-19719A
    Miransertib hydrochloride
    Inhibitor
    Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
  • HY-139854
    DNDI-6148
    DNDI-6148 is a novel preclinical candidate for the treatment of visceral leishmaniasis.
  • HY-120060
    GNF6702
    GNF6702 is a selective inhibitor of the kinetoplastid proteasome.
  • HY-B0537C
    Pentamidine dimesylate
    Inhibitor
    Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics.
  • HY-146042
    Antiparasitic agent-4
    Inhibitor
    Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L.
  • HY-120154
    Palitantin
    Inhibitor
    Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis.
  • HY-N10441
    3β-Hydroxy-hop-22(29)-ene
    Inhibitor
    3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent.
  • HY-N7985
    Pendulone
    Inhibitor
    Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 µM.
  • HY-125648
    Euphorbadienol
    Inhibitor
    Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera.
  • HY-146041
    Antiparasitic agent-2
    Inhibitor
    Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L.