Hypocrellin B 

Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities^[1][2][3].

Hypocrellin B (2.5 μM, 4 h) induces cell cytotoxicity 24 h after sonodynamic therapy (SDT) in HepG2 cells, and induces induce the early apoptosis^[2].
Hypocrellin B shows antifungal and anti-parasite activity against C. albicans and Leishmania donovani respectively (IC₅₀: 5 and 12.7 μg/mL)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hypocrellin B (2 mg/kg, i.v.) inhibits tumor growth in A549 tumor bearing mice, but the anticancer efficacy is less than hypocrellin B loaded nanoparticles^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

528.51

C₃₀H₂₄O₉

123940-54-5

Solid

Brown to black

CC(C1)=C(C(C)=O)C(C2=C(C3=C(O)C=C4OC)C4=C5C(OC)=CC(O)=C6C5=C2C1=C(OC)C6=O)=C(OC)C3=O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.