Antimicrobial and antileishmanial activities of hypocrellins A and B

  • Antimicrob Agents Chemother. 2004 Nov;48(11):4450-2. doi: 10.1128/AAC.48.11.4450-4452.2004.
Guoyi Ma  1 ,  Shabana I Khan ,  Melissa R Jacob ,  Babu L Tekwani ,  Zuqiang Li ,  David S Pasco ,  Larry A Walker ,  Ikhlas A Khan
Affiliations
  • 1. The National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
PMID: 15504880 DOI: 10.1128/AAC.48.11.4450-4452.2004
Abstract

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising Antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

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