1. Signaling Pathways
  2. Anti-infection
  3. Parasite
  4. Leishmania Isoform


Members of the Leishmania genus are obligate, intracellular vector-borne protozoa which can cause a wide spectrum of disease, ranging from asymptomatic infection to diffuse or localized cutaneous leishmaniasis (CL), visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL). Leishmania spp. are members of the order Kinetoplastida due to the presence of a kinetoplast. Leishmaniasis remains a neglected tropical disease, with approximately 310 million individuals at risk for contracting the infection, 12 million people currently infected, and an annual incidence of 2 million new infections. There are two major forms of the parasite, the extracellular promastigote found in the sand fly and the intracellular amastigote found in vertebrate hosts. While the classic mode of Leishmania transmission is through the bite of an infected sand fly, infection through contaminated needles shared among intravenous drug users, blood transfusion, organ transplantation and vertical transmission have also been documented, albeit rarely.

Leishmania Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-19719
    Inhibitor 99.33%
    Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
  • HY-N2575
    Hypocrellin A
    Inhibitor 99.56%
    Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities.
  • HY-B0537B
    Pentamidine isethionate
    Inhibitor 99.82%
    Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics.
  • HY-103353
    SID 26681509
    Inhibitor 98.26%
    SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM.
  • HY-101397
    Allopurinol riboside
    Inhibitor 99.04%
    Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.
  • HY-127087
    Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively.
  • HY-N2894
    Piperolactam A
    Piperolactam A is a natural product that can be isolated from root of Piper betle.
  • HY-N1453
    Hypocrellin B
    Inhibitor 99.61%
    Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer.
  • HY-N6961
    Inhibitor 99.06%
    Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae).
  • HY-N0769
    Inhibitor 99.69%
    Isopimpinellin, an orally active compound isolated from Glomerella cingulata.
  • HY-N0397
    Inhibitor 99.97%
    Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.
  • HY-N7906
    Myricetin 3-O-glucoside
    Inhibitor ≥99.0%
    Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica.
  • HY-147428
    Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC50 of 0.90 μM to combat addiction.
  • HY-U00128
    Inhibitor 99.31%
    PPA-904 is a specific phenothiazine photosensitizer in photodynamic therapy (PDT) research, especially topical application for cutaneous leishmaniasis in vivo.
  • HY-19719A
    Miransertib hydrochloride
    Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
  • HY-139854
    DNDI-6148 is a novel preclinical candidate for the treatment of visceral leishmaniasis.
  • HY-120060
    GNF6702 is a selective inhibitor of the kinetoplastid proteasome.
  • HY-B0537C
    Pentamidine dimesylate
    Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics.
  • HY-146042
    Antiparasitic agent-4
    Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L.
  • HY-120154
    Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis.