Leishmania

Members of the Leishmania genus are obligate, intracellular vector-borne protozoa which can cause a wide spectrum of disease, ranging from asymptomatic infection to diffuse or localized cutaneous leishmaniasis (CL), visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL). Leishmania spp. are members of the order Kinetoplastida due to the presence of a kinetoplast. Leishmaniasis remains a neglected tropical disease, with approximately 310 million individuals at risk for contracting the infection, 12 million people currently infected, and an annual incidence of 2 million new infections. There are two major forms of the parasite, the extracellular promastigote found in the sand fly and the intracellular amastigote found in vertebrate hosts. While the classic mode of Leishmania transmission is through the bite of an infected sand fly, infection through contaminated needles shared among intravenous drug users, blood transfusion, organ transplantation and vertical transmission have also been documented, albeit rarely.

Leishmania Inhibitors (28)

Leishmania Related Products (30):

By Type:	Pan (1) Selective (1)

Cat. No.	Product Name	Effect	Purity

HY-19719

Miransertib	Inhibitor	99.33%
Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC₅₀s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.

HY-N2575

Hypocrellin A	Inhibitor	99.56%
Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities.

HY-B0537B

Pentamidine isethionate	Inhibitor	99.82%
Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics.

HY-103353

SID 26681509	Inhibitor	98.26%
SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC₅₀ of 56 nM.

HY-101397

Allopurinol riboside	Inhibitor	99.04%
Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

HY-127087

Isogarcinol	Inhibitor
Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC₅₀ values of 1.13 and 8.30 μM, respectively.

HY-N2894

Piperolactam A	Inhibitor
Piperolactam A is a natural product that can be isolated from root of Piper betle.

HY-N1453

Hypocrellin B	Inhibitor	99.61%
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer.

HY-N6961

Lapachol	Inhibitor	99.06%
Lapachol is a naphthoquinone that was first isolated from Tabebuia avellanedae (Bignoniaceae).

HY-N0769

Isopimpinellin	Inhibitor	99.69%
Isopimpinellin, an orally active compound isolated from Glomerella cingulata.

HY-N0397

Harpagide	Inhibitor	99.97%
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.

HY-N7906

Myricetin 3-O-glucoside	Inhibitor	≥99.0%
Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica.

HY-147428

Zolunicant	Inhibitor
Zolunicant (MM-110) is a potent inhibitor against nicotinic α3β4 receptors with an IC₅₀ of 0.90 μM to combat addiction.

HY-U00128

PPA-904	Inhibitor	99.31%
PPA-904 is a specific phenothiazine photosensitizer in photodynamic therapy (PDT) research, especially topical application for cutaneous leishmaniasis in vivo.

HY-19719A

Miransertib hydrochloride	Inhibitor
Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC₅₀s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.

HY-139854

DNDI-6148
DNDI-6148 is a novel preclinical candidate for the treatment of visceral leishmaniasis.

HY-120060

GNF6702
GNF6702 is a selective inhibitor of the kinetoplastid proteasome.

HY-B0537C

Pentamidine dimesylate	Inhibitor
Pentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics.

HY-146042

Antiparasitic agent-4	Inhibitor
Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L.

HY-120154

Palitantin	Inhibitor
Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis.

Name
Email *

	Sorry, but the email address you supplied was invalid.