1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    Parasite
  3. Isopimpinellin

Isopimpinellin 

Cat. No.: HY-N0769
Handling Instructions

Isopimpinellin, an orally active compound isolated from the roots of Pimpinella saxifrage. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect.

For research use only. We do not sell to patients.

Isopimpinellin Chemical Structure

Isopimpinellin Chemical Structure

CAS No. : 482-27-9

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Description

Isopimpinellin, an orally active compound isolated from the roots of Pimpinella saxifrage. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect[1].

In Vivo

Isopimpinellin (oral gavage, 35-150 mg/kg) inhibits B[a]P-DNA adduct formation and DMBA–DNA adduct formation in SENCAR mice with skin tumor[1].

Animal Model: Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study[1].
Dosage: 35–150 mg/kg.
Administration: Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone).
Result: Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively.
Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively
Molecular Weight

246.22

Formula

C₁₃H₁₀O₅

CAS No.

482-27-9

SMILES

O=C1C=CC2=C(OC)C3=C(OC=C3)C(OC)=C2O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

IsopimpinellinDNA/RNA SynthesisParasiteInhibitorinhibitorinhibit

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