Coccidia
Coccidia comprise protozoan parasites including Toxoplasma gondii, Neospora caninum, Eimeria spp., and Cystoisospora spp., and their life cycle switches between asexual and sexual stages[1]. Mechanistically, Eimeria invasion depends on coccidian organelles and host-cell interaction during intestinal infection[2][3]. In poultry models, Eimeria invades the intestinal tract and causes coccidiosis, with disease severity and lesions varying by parasite species[4][3]. Compared with T. gondii, which infects warm-blooded animals asexually but restricts sexual development to felines, Eimeria usually completes its whole life cycle in one host species[5]. For experimental applications, monolayer cultures, organoids, axenic systems, and host cell-free Cystoisospora suis models support research on parasite development, invasion, host-parasite interaction, and anticoccidial drug targets[1][6].
References:
- [1]. Feix AS, et al. In vitro cultivation methods for coccidian parasite research. Int J Parasitol. 2023 Aug;53(9):477-489. [Content Brief]
- [2]. Burrell A, et al. Life cycle stages, specific organelles and invasion mechanisms of Eimeria species. Parasitology. 2020 Mar;147(3):263-278. [Content Brief]
- [3]. López-Osorio S, et al. Overview of Poultry Eimeria Life Cycle and Host-Parasite Interactions. Front Vet Sci. 2020 Jul 3;7:384. [Content Brief]
- [4]. Mesa-Pineda C, et al. Chicken Coccidiosis: From the Parasite Lifecycle to Control of the Disease. Front Vet Sci. 2021 Dec 21;8:787653. [Content Brief]
- [5]. Martorelli Di Genova B, et al. Comparisons of the Sexual Cycles for the Coccidian Parasites Eimeria and Toxoplasma. Front Cell Infect Microbiol. 2020 Dec 14;10:604897. [Content Brief]
- [6]. Feix AS, et al. Progression of asexual to sexual stages of Cystoisospora suis in a host cell-free environment as a model for Coccidia. Parasitology. 2021 Oct;148(12):1475-1481. [Content Brief]
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Coccidia Related Products (27)
Related Products (27)
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Salinomycin
0 ImagesSynonyms: ProcoxacinSalinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells.
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Toltrazuril sulfone
0 ImagesSynonyms: PonazurilToltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry.
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Diclazuril
0 ImagesSynonyms: R-64433Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
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Robenidine hydrochloride
0 ImagesRobenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.
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Chloroquinoxaline sulfonamide
0 ImagesSynonyms: Chloroquinoxaline; NSC-339004Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.
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Narasin
0 ImagesCat. No.: HY-121410CAS No.: 55134-13-9Narasin is a cationic ionophore antibiotic and coccidiostat agent. Narasin inhibits NF-κB signaling and induces tumor cells apoptosis. Narasin has antimicrobial, antiviral anticancer activity. Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF-β/SMAD3 and IL‑6/STAT3 signaling pathways.
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Sulfaclozine sodium
0 ImagesSynonyms: Sulfachloropyrazine sodiumSulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
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Decoquinate
0 ImagesDecoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry.
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Diclazuril-d4
0 ImagesCat. No.: HY-B0357SCAS No.: 1632495-80-7Synonyms: R-64433-d4Diclazuril-d4 is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.
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Amprolium hydrochloride
0 ImagesAmprolium hydrochloride is an anti-parasitic drug that's kind of taken orally, and it acts as an antagonist to thiamine in intestinal absorption.
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Robenidine-d8 hydrochloride
0 ImagesRobenidine-d8 (hydrochloride) is the deuterium labeled Robenidine hydrochloride. Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC50s of 8.1 and 4.7 μM, respectively.
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Sulfaclozine
0 ImagesSulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
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Nicarbazin-d8
0 ImagesCat. No.: HY-107814SPurity: 99.99%Nicarbazin-d8 is deuterium labeled Nicarbazin. Nicarbazin is an effective anticoccidial agent for chickens.
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Toltrazuril sulfoxide
0 ImagesToltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
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Dinitolmide
0 ImagesDinitolmide (Zoalene) is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC50 of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella.
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