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  2. Parasite
  3. Toltrazuril (sulfone)

Toltrazuril (sulfone)  (Synonyms: Ponazuril)

Cat. No.: HY-17008 Purity: 98.58%
COA Handling Instructions

Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry.

For research use only. We do not sell to patients.

Toltrazuril (sulfone) Chemical Structure

Toltrazuril (sulfone) Chemical Structure

CAS No. : 69004-04-2

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10 mM * 1 mL in DMSO
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Solid
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10 mg USD 55 In-stock
50 mg USD 125 In-stock
100 mg USD 145 In-stock
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Other Forms of Toltrazuril (sulfone):

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Description

Toltrazuril sulfone (Ponazuril) is a metabolite of Toltrazuril (HY-B0175), with antiprotozoal activity. Toltrazuril sulfone is a triazine anticoccidial that is developed to prevent coccidiosis in poultry[1][2].

IC50 & Target

Coccidia

 

In Vitro

Toltrazuril sulfone inhibits the development of merozoites of S. neurona[1].
Toltrazuril sulfone inhibits the development of N. caninum after approximately 48 h post-exposure[1].
Toltrazuril sulfone exhibits inhibitory possibly by targeting different enzyme/enzyme systems in different apicomplexans[1].
Toltrazuril sulfone (5 mg/ml; 20 hours) inhibits T. gondii replication after the second division by endodyogeny[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Toltrazuril sulfone (10-20 mg/kg; p.o.; daily; for 10 days) is effective in preventing and treating toxoplasmosis in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice[2]
Dosage: 10 mg/kg, 20 mg/kg
Administration: Oral administration, daily, for 10 days
Result: Prevented and protected mice from toxoplasmosis.
Molecular Weight

457.38

Formula

C18H14F3N3O6S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C=C1)OC2=C(C=C(C=C2)N3C(N(C(NC3=O)=O)C)=O)C)(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (109.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1864 mL 10.9318 mL 21.8637 mL
5 mM 0.4373 mL 2.1864 mL 4.3727 mL
10 mM 0.2186 mL 1.0932 mL 2.1864 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.47 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Toltrazuril (sulfone) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Toltrazuril (sulfone)
Cat. No.:
HY-17008
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