1. Anti-infection
    Metabolic Enzyme/Protease
  2. Parasite
    Drug Metabolite
    Endogenous Metabolite
  3. Allopurinol riboside

Allopurinol riboside 

Cat. No.: HY-101397 Purity: 99.04%
Handling Instructions

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

For research use only. We do not sell to patients.

Allopurinol riboside Chemical Structure

Allopurinol riboside Chemical Structure

CAS No. : 16220-07-8

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10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Allopurinol-riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM. Lymphocyte blastogensis induced by PHA and Con A is significantly suppressed by allopurinol-riboside in a concentration-dependent manner. When LPS is used as a mitogen, the inhibition of allopurinol-ribosideon lymphocyte proliferation is less marked. Humoral immunity is not suppressed by allopurinol-riboside[1]. Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Allopurinol riboside is effective against parasites, because a series of enzymes (analogous to those that mediate purine salvage in humans) convert it into 4-aminopyrazolopyrimidine ribonucleoside triphosphate, a cytotoxic product. Allopurinol riboside is selectively toxic, because it is not metabolized by the corresponding enzymes in humans[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range[3]. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

268.23

Formula

C₁₀H₁₂N₄O₅

CAS No.

16220-07-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: 99.04%

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Keywords:

Allopurinol ribosideParasiteDrug MetaboliteEndogenous MetaboliteInhibitorinhibitorinhibit

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Product Name:
Allopurinol riboside
Cat. No.:
HY-101397
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