18507-89-6
Chemical Structure
Decoquinate
- CAS No.: 18507-89-6
- Formula:C24H35NO5
- Molecular Weight:417.54
IUPAC Name: ethyl 6-(decyloxy)-7-ethoxy-4-hydroxyquinoline-3-carboxylate
InChIKey: JHAYEQICABJSTP-UHFFFAOYSA-N
SMILES: O=C(C1=C(O)C2=CC(OCCCCCCCCCC)=C(OCC)C=C2N=C1)OCC
Biological Activity: Decoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry[1][2][3].
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Decoquinate | 98.80% | Decoquinate is an orally active, selective inhibitor of the mitochondrial bc1 complex, targeting Eimeria spp. sporozoites and first generation schizonts, and Plasmodium spp. Decoquinate inhibits electron transfer by competitively binding to the mitochondrial cytochrome b system, blocking the parasite's energy metabolism, thereby inhibiting its development and reproduction. Decoquinate has significant anticoccidial activity, preventing intestinal damage and improving host growth performance, and also has inhibitory effects on the liver and blood stages of Plasmodium. Decoquinate is mainly used in veterinary research to prevent and treat coccidiosis in ruminants and poultry. | ||||||||||||||||||||
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Decoquinate (Standard) | ≥98% | Decoquinate (Standard) is the analytical standard of Decoquinate. This product is intended for research and analytical applications. Decoquinate is a quinolone derivative that can be used for research of coccidiosis in domestic ruminants. Decoquinate also has potent activity against both Plasmodium hepatic development and red cell replication. | ||||||||||||||||||||
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- [1]. Taylor MA, et, al. The history of decoquinate in the control of coccidial infections in ruminants. J Vet Pharmacol Ther. 2012 Oct;35(5):417-27. [Content Brief]
- [2]. Wang H, et al. Nanoparticle formulations of decoquinate increase antimalarial efficacy against liver stage Plasmodium infections in mice. Nanomedicine. 2014 Jan;10(1):57-65. [Content Brief]
- [3]. Beteck RM, et al. Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3006-3009. [Content Brief]
Keywords
