1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Chloroquinoxaline sulfonamide

Chloroquinoxaline sulfonamide (Synonyms: Chloroquinoxaline; NSC-339004)

Cat. No.: HY-106662 Purity: 99.47%
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Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.

For research use only. We do not sell to patients.

Chloroquinoxaline sulfonamide Chemical Structure

Chloroquinoxaline sulfonamide Chemical Structure

CAS No. : 97919-22-7

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10 mM * 1  mL in DMSO USD 182 In-stock
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50 mg USD 1050 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle[1]. Antitumor activity[2].

IC50 & Target[1]

topoisomerase II alpha

 

topoisomerase II beta

 

In Vitro

The Chloroquinoxaline sulfonamide IC50 for CV-1cells, obtained using an MTT cytotoxicity assay, was 1.8 mM. Chloroquinoxaline sulfonamide causes dose-dependent protein-DNA cross-links to CV-1 monkey kidney cell chromosomal DNA when drug treatment was terminated by lysis with GuHCl. Chloroquinoxaline sulfonamide-induced protein-DNA cross-links in CV-1 cells. Chloroquinoxaline sulfonamide-induced topoisomerase II-DNA cross-links[1].
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a chlorinated derivative of sulfaquinoxaline, inhibits proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) are used[2].

Cell Proliferation Assay[2]

Cell Line: B16 murine melanoma cells
Concentration: 10 μM, 100 μM, 1 mM
Incubation Time: 24, 48, 72 hours
Result: Inhibited proliferation of murine B16 melanoma cells, but only when relatively high drug concentrations (1 mM) were used.
Clinical Trial
Molecular Weight

334.78

Formula

C₁₄H₁₁ClN₄O₂S

CAS No.

97919-22-7

SMILES

ClC1=CC=CC2=NC(NS(=O)(C3=CC=C(N)C=C3)=O)=CN=C12

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (373.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9870 mL 14.9352 mL 29.8704 mL
5 mM 0.5974 mL 2.9870 mL 5.9741 mL
10 mM 0.2987 mL 1.4935 mL 2.9870 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.21 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Chloroquinoxaline sulfonamideChloroquinoxalineNSC-339004NSC339004NSC 339004Topoisomeraseanaloguepoisoncoccidiosisantitumortopoisomerase-DNA,?cross-linksbreastproliferationmelanomaovariancarcinomasInhibitorinhibitorinhibit

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Chloroquinoxaline sulfonamide
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HY-106662
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