2. Anti-infection
  3. Bacterial Parasite Antibiotic
  4. Sulfaclozine sodium

Sulfaclozine sodium  (Synonyms: Sulfachloropyrazine sodium)

Cat. No.: HY-19285A Purity: 99.20%
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Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).

For research use only. We do not sell to patients.

Sulfaclozine sodium Chemical Structure

Sulfaclozine sodium Chemical Structure

CAS No. : 23307-72-4

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sulfaclozine sodium:

Sulfaclozine sodium Related Antibodies

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Description

Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)[1].

IC50 & Target

Coccidia

 

In Vitro

The elimination of Sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Sulfaclozine is weakly adsorbed on the surface of TiO2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of •OH and SO4•− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfaclozine sodium Related Antibodies
In Vivo

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 14 male broiler chickens (30-day-old)[1]
Dosage: 60 mg/kg
Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
Molecular Weight

306.70

Formula

C10H8ClN4NaO2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(C1=CC=C(N)C=C1)(N([Na])C2=NC(Cl)=CN=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (163.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2605 mL 16.3026 mL 32.6051 mL
5 mM 0.6521 mL 3.2605 mL 6.5210 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2605 mL 16.3026 mL 32.6052 mL 81.5129 mL
5 mM 0.6521 mL 3.2605 mL 6.5210 mL 16.3026 mL
10 mM 0.3261 mL 1.6303 mL 3.2605 mL 8.1513 mL
15 mM 0.2174 mL 1.0868 mL 2.1737 mL 5.4342 mL
20 mM 0.1630 mL 0.8151 mL 1.6303 mL 4.0756 mL
25 mM 0.1304 mL 0.6521 mL 1.3042 mL 3.2605 mL
30 mM 0.1087 mL 0.5434 mL 1.0868 mL 2.7171 mL
40 mM 0.0815 mL 0.4076 mL 0.8151 mL 2.0378 mL
50 mM 0.0652 mL 0.3261 mL 0.6521 mL 1.6303 mL
60 mM 0.0543 mL 0.2717 mL 0.5434 mL 1.3585 mL
80 mM 0.0408 mL 0.2038 mL 0.4076 mL 1.0189 mL
100 mM 0.0326 mL 0.1630 mL 0.3261 mL 0.8151 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sulfaclozine sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfaclozine23307-72-4SulfachloropyrazineBacterialParasiteAntibioticEfficacioussulphonamideantibacterialanticoccidialpoultrydiseasespharmacokineticsInhibitorinhibitorinhibit

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