Sulfaclozine sodium
Based on 1 Customer Validation
Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 23307-72-4
- Formula: C10H8ClN4NaO2S
- Molecular Weight:306.70
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Coccidia |
The elimination of Sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Sulfaclozine is weakly adsorbed on the surface of TiO2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of ?OH and SO4?? radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:14 male broiler chickens (30-day-old)[1]
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Dosage:60 mg/kg
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Administration:Intravenous injection or oral administration (Pharmacokinetic Analysis)
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Result:Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
Chemical Information
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CAS No. 23307-72-4
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Appearance Solid
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Molecular Weight 306.70
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Formula C10H8ClN4NaO2S
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Color Light yellow to yellow
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SMILES
O=S(C1=CC=C(N)C=C1)(N([Na])C2=NC(Cl)=CN=C2)=O
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Synonyms
Sulfachloropyrazine sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (163.03 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sentepe I, et al. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010 Jan;48(1):448-451. [Content Brief]
[2]. Ismail L, et al. Effect of water constituents on the degradation of sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Environ Sci Pollut Res Int. 2018 Jan;25(3):2651-2663. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2605 mL | 16.3026 mL | 32.6052 mL | 81.5129 mL |
| 5 mM | 0.6521 mL | 3.2605 mL | 6.5210 mL | 16.3026 mL | |
| 10 mM | 0.3261 mL | 1.6303 mL | 3.2605 mL | 8.1513 mL | |
| 15 mM | 0.2174 mL | 1.0868 mL | 2.1737 mL | 5.4342 mL | |
| 20 mM | 0.1630 mL | 0.8151 mL | 1.6303 mL | 4.0756 mL | |
| 25 mM | 0.1304 mL | 0.6521 mL | 1.3042 mL | 3.2605 mL | |
| 30 mM | 0.1087 mL | 0.5434 mL | 1.0868 mL | 2.7171 mL | |
| 40 mM | 0.0815 mL | 0.4076 mL | 0.8151 mL | 2.0378 mL | |
| 50 mM | 0.0652 mL | 0.3261 mL | 0.6521 mL | 1.6303 mL | |
| 60 mM | 0.0543 mL | 0.2717 mL | 0.5434 mL | 1.3585 mL | |
| 80 mM | 0.0408 mL | 0.2038 mL | 0.4076 mL | 1.0189 mL | |
| 100 mM | 0.0326 mL | 0.1630 mL | 0.3261 mL | 0.8151 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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