1. Anti-infection
  2. Bacterial
    Parasite
  3. Sulfaclozine sodium

Sulfaclozine sodium (Synonyms: Sulfachloropyrazine sodium)

Cat. No.: HY-19285A Purity: 98.89%
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Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis).

For research use only. We do not sell to patients.

Sulfaclozine sodium Chemical Structure

Sulfaclozine sodium Chemical Structure

CAS No. : 23307-72-4

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Based on 1 publication(s) in Google Scholar

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Description

Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)[1].

IC50 & Target

Bacterial; Parasite[1]

In Vitro

The elimination of Sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Sulfaclozine is weakly adsorbed on the surface of TiO2 at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8 in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of OH and SO4•− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals[2].

In Vivo

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections[1].

Animal Model: 14 male broiler chickens (30-day-old)[1]
Dosage: 60 mg/kg
Administration: Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result: Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
Molecular Weight

306.70

Formula

C₁₀H₈ClN₄NaO₂S

CAS No.

23307-72-4

SMILES

O=S(C1=CC=C(N)C=C1)([N-]C2=NC(Cl)=CN=C2)=O.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

SulfaclozineSulfachloropyrazineBacterialParasiteEfficacioussulphonamideantibacterialanticoccidialpoultrydiseasespharmacokineticsInhibitorinhibitorinhibit

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