Sulfaclozine  (Synonyms: Sulfachloropyrazine)

Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)^[1].

The elimination of Sulfaclozine in the three systems: UV/TiO₂, UV/K₂S₂O₈, and UV/TiO₂/K₂S₂O₈. Sulfaclozine is weakly adsorbed on the surface of TiO₂ at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO₂, UV/K₂S₂O₈, and UV/TiO₂/K₂S₂O₈ in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of ^•OH and SO₄^•− radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

284.72

C₁₀H₉ClN₄O₂S

102-65-8

O=S(C1=CC=C(N)C=C1)(NC2=NC(Cl)=CN=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sentepe I, et al. Pharmacokinetic of sulfaclozine in broiler chickens. Food Chem Toxicol. 2010 Jan;48(1):448-451.  [Content Brief]

  [2]. Ismail L, et al. Effect of water constituents on the degradation of sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Environ Sci Pollut Res Int. 2018 Jan;25(3):2651-2663.  [Content Brief]