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  2. Bacterial
    Parasite
    Antibiotic
  3. Sulfadiazine

Sulfadiazine 

Cat. No.: HY-B0273 Purity: 99.86%
COA Handling Instructions

Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research.

For research use only. We do not sell to patients.

Sulfadiazine Chemical Structure

Sulfadiazine Chemical Structure

CAS No. : 68-35-9

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Solution
10 mM * 1 mL in DMSO USD 67 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
500 mg USD 61 In-stock
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5 g USD 106 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sulfadiazine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sulfadiazine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research[1][2].

IC50 & Target

Toxoplasma

 

In Vivo

In this study, the effectiveness of Sulfadiazine and Pyrimetamine for the treatment of mice during acute infection with different atypical T. gondii strains was evaluated. Swiss mice were infected with seven T. gondii strainsl. The infected mice were treated with 10-640 mg/kg per day of Sulfadiazine, 3-200 mg/kg per day of Pyrimetamine, or a combination of both drugs with a lower dosage. A descriptive analysis was used to assess the association between susceptibility to Sulfadiazine and/or Pyrimetamine and the genotype. The TgCTBr4 and TgCTBr17 strains (genotype 108) presented lower susceptibility to Sulfadiazine or Pyrimetamine treatment. The TgCTBr1 and TgCTBr25 strains (genotype 206) presented similar susceptibility to PYR but not Sulfadiazine treatment. The TgCTBr9 strain (genotype 11) was the only strain with high susceptibility to treatment with both drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

250.28

Formula

C10H10N4O2S

CAS No.
SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC=CC=N2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (199.78 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9955 mL 19.9776 mL 39.9552 mL
5 mM 0.7991 mL 3.9955 mL 7.9911 mL
10 mM 0.3996 mL 1.9978 mL 3.9955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (9.99 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Sulfadiazine
Cat. No.:
HY-B0273
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