1. Anti-infection
  2. Bacterial
    Parasite
  3. Sulfadiazine

Sulfadiazine 

Cat. No.: HY-B0273 Purity: 99.83%
Handling Instructions

Sulfadiazine belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine is also used for toxoplasmosis.

For research use only. We do not sell to patients.

Sulfadiazine Chemical Structure

Sulfadiazine Chemical Structure

CAS No. : 68-35-9

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
500 mg USD 55 In-stock
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5 g USD 96 In-stock
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Description

Sulfadiazine belongs to the class of sulfonamide antibiotics that are used for veterinary purposes worldwide, mainly in pig production. Sulfadiazine is also used for toxoplasmosis[1][2].

In Vivo

In this study, the effectiveness of Sulfadiazine and Pyrimetamine for the treatment of mice during acute infection with different atypical T. gondii strains was evaluated. Swiss mice were infected with seven T. gondii strainsl. The infected mice were treated with 10-640 mg/kg per day of Sulfadiazine, 3-200 mg/kg per day of Pyrimetamine, or a combination of both drugs with a lower dosage. A descriptive analysis was used to assess the association between susceptibility to Sulfadiazine and/or Pyrimetamine and the genotype. The TgCTBr4 and TgCTBr17 strains (genotype 108) presented lower susceptibility to Sulfadiazine or Pyrimetamine treatment. The TgCTBr1 and TgCTBr25 strains (genotype 206) presented similar susceptibility to PYR but not Sulfadiazine treatment. The TgCTBr9 strain (genotype 11) was the only strain with high susceptibility to treatment with both drugs[1].

Clinical Trial
Molecular Weight

250.28

Formula

C₁₀H₁₀N₄O₂S

CAS No.

68-35-9

SMILES

O=S(C1=CC=C(N)C=C1)(NC2=NC=CC=N2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (199.78 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9955 mL 19.9776 mL 39.9552 mL
5 mM 0.7991 mL 3.9955 mL 7.9911 mL
10 mM 0.3996 mL 1.9978 mL 3.9955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (9.99 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SulfadiazineBacterialParasitesulfonamideantibioticveterinarypigtoxoplasmosisInhibitorinhibitorinhibit

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