2. Disease Areas
  3. Infection
  4. Parasitic Infection
  5. Toxoplasma Infection

Toxoplasma Infection

Toxoplasma gondii is a globally distributed intracellular protozoan parasite belonging to the phylum Apicomplexa, closely related to pathogens such as Plasmodium, Cryptosporidium, and Eimeria. It infects a wide range of warm-blooded animals, including humans, with an estimated one-third of the global population harboring latent infection. The parasite exhibits a complex life cycle involving both sexual and asexual phases. In intermediate hosts, including humans, the asexual cycle features two key stages: rapidly dividing tachyzoites responsible for acute disease and disseminated infection, and slow-growing bradyzoites that form tissue cysts, enabling lifelong chronic infection. Transmission occurs primarily through ingestion of undercooked meat containing tissue cysts or consumption of food and water contaminated with oocysts shed in the feces of infected cats—the definitive host—where the sexual cycle takes place. This cycle produces millions of environmentally resistant oocysts capable of initiating new infections. The ability of T. gondii to switch between tachyzoite and bradyzoite forms is crucial for immune evasion, persistence, and transmission across hosts. While both cycles contribute to its success, the relative importance of each in maintaining the parasite’s global prevalence remains incompletely understood.

References:

Toxoplasma Infection (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15157
    Calcitetrol 72203-93-1 99.94%
    Calcitetrol (1α, 24, 25-Trihydroxy VD3), a Vitamin D3 (HY-15398) metabolite, is the hormonally active form of vitamin D. Calcitetrol participates in regulation of Treg cells. Calcitetrol can be used for the research of Toxoplasma gondii infection.
    Calcitetrol
  • HY-120808
    GSK2188764 1849587-68-3
    GSK2188764 is a Toxoplasma gondii rhoptry protein 18 (ROP18) inhibitor with reported IC50 values of 7.49 μM against Toxoplasma gondii. GSK2188764 inhibits serine-threonine kinase activity of ROP18 in vitro.GSK2188764 can be used for the research of toxoplasmosis.
    GSK2188764
  • HY-B0273B
    Sulfadiazine 100 µg/mL in methanol 68-35-9 99.68%
    Sulfadiazine 100 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadiazine 100 µg/mL in methanol competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine 100 µg/mL in methanol persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine 100 µg/mL in methanol targets Toxoplasma gondii DHPS enzyme. Sulfadiazine 100 µg/mL in methanol can be used for the research of congenital toxoplasmosis and bacterial infection.
    Sulfadiazine 100 µg/mL in methanol
  • HY-183286
    DHFR-IN-27
    DHFR-IN-27 (Compound LA4) is an orally active DHFR inhibitor and antimalarial agent, with a Ki value of 1.71 nM against TgDHFR. DHFR-IN-27 reduces the parasitic load of Toxoplasma gondii in infected mice and prolongs the survival time of infected mice. DHFR-IN-27 exerts Antiparasitic effects against Toxoplasma gondii. DHFR-IN-27 can be used in the research of toxoplasmosis.
    DHFR-IN-27
  • HY-P11767
    NCR247 1372669-36-7
    NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and haem sequesterer. NCR247 forms 6:6 haem:NCR247 hexamers and higher-order complexes to render haem and bound iron biologically inaccessible, induces iron-starvation response in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity.NCR247 is critical for establishing nitrogen-fixing symbiosis between Sinorhizobium meliloti and Medicago truncatula, and is inactive against cytochrome haem.NCR247’s D-enantiomer binds and sequesters haem equivalently to its L-enantiomer.NCR247 can be used for the research of infections, periodontal disease, toxoplasmosis.
    NCR247