2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. VD/VDR Drug Metabolite
  4. Calcitetrol

Calcitetrol  (Synonyms: 1α, 24, 25-Trihydroxy VD3)

Cat. No.: HY-15157 Purity: 99.94%
COA
SDS
Handling Instructions Technical Support

Calcitetrol (1α, 24, 25-Trihydroxy VD3), a Vitamin D3 (HY-15398) metabolite, is the hormonally active form of vitamin D. Calcitetrol participates in regulation of Treg cells. Calcitetrol can be used for the research of Toxoplasma gondii infection.

For research use only. We do not sell to patients.

Calcitetrol

Calcitetrol Chemical Structure

CAS No. : 72203-93-1

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Calcitetrol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Calcitetrol (1α, 24, 25-Trihydroxy VD3), a Vitamin D3 (HY-15398) metabolite, is the hormonally active form of vitamin D. Calcitetrol participates in regulation of Treg cells. Calcitetrol can be used for the research of Toxoplasma gondii infection[1].

In Vitro

Calcitetrol undergoes further metabolism by recombinant rat kidney calcidiol 24-hydroxylase (P450cc24) into 24-oxo-1,25-dihydroxyvitamin D3, which converts to 24-oxo-1,23,25-trihydroxyvitamin D3[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Calcitetrol Related Antibodies
In Vivo

Calcitetrol is upregulated in the cerebral cortex of T. gondii-infected BALB/C mice at 14 and 21 days post-infection and qualifies as a T. gondii-responsive metabolite[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

432.64

Formula

C27H44O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@@H]3[C@@H](CCC(O)C(C)(O)C)C)([H])[C@]3(C)CCC\2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (231.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3114 mL 11.5570 mL 23.1139 mL
5 mM 0.4623 mL 2.3114 mL 4.6228 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (252 KB)

COA (252 KB) LCMS (340 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3114 mL 11.5570 mL 23.1139 mL 57.7848 mL
5 mM 0.4623 mL 2.3114 mL 4.6228 mL 11.5570 mL
10 mM 0.2311 mL 1.1557 mL 2.3114 mL 5.7785 mL
15 mM 0.1541 mL 0.7705 mL 1.5409 mL 3.8523 mL
20 mM 0.1156 mL 0.5778 mL 1.1557 mL 2.8892 mL
25 mM 0.0925 mL 0.4623 mL 0.9246 mL 2.3114 mL
30 mM 0.0770 mL 0.3852 mL 0.7705 mL 1.9262 mL
40 mM 0.0578 mL 0.2889 mL 0.5778 mL 1.4446 mL
50 mM 0.0462 mL 0.2311 mL 0.4623 mL 1.1557 mL
60 mM 0.0385 mL 0.1926 mL 0.3852 mL 0.9631 mL
80 mM 0.0289 mL 0.1445 mL 0.2889 mL 0.7223 mL
100 mM 0.0231 mL 0.1156 mL 0.2311 mL 0.5778 mL
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Calcitetrol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calcitetrol72203-93-11α, 24, 25-Trihydroxy VD3VD/VDRDrug MetaboliteVitamin DVitamin D receptorrecombinant rat kidney calcidiol 24-hydroxylasecalcitriolTreg cellsP450cc2424-oxo-1,25-dihydroxyvitamin D3mouse cerebral cortex24-oxo-1,23,25-trihydroxyvitamin D3BALB/C miceToxoplasma gondiiInhibitorinhibitorinhibit

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