1. Vitamin D Related
    Metabolic Enzyme/Protease
  2. VD/VDR
    Endogenous Metabolite
  3. Cholecalciferol

Cholecalciferol (Synonyms: Vitamin D3; Colecalciferol)

Cat. No.: HY-15398 Purity: >98.0%
Handling Instructions

Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells.

For research use only. We do not sell to patients.

Cholecalciferol Chemical Structure

Cholecalciferol Chemical Structure

CAS No. : 67-97-0

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Free Sample (0.5-1 mg)   Apply now  
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
1 g USD 180 In-stock
Estimated Time of Arrival: December 31
5 g USD 359 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value: Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

384.64

Formula

C₂₇H₄₄O

CAS No.

67-97-0

SMILES

C[[email protected]@]12[[email protected]](CC[[email protected]]2([H])[[email protected]](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C(CC[[email protected]](O)C\3)=C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (26.00 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5998 mL 12.9992 mL 25.9983 mL
5 mM 0.5200 mL 2.5998 mL 5.1997 mL
10 mM 0.2600 mL 1.2999 mL 2.5998 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.41 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

CholecalciferolVitamin D3ColecalciferolVitamin D 3Vitamin D-3VD/VDREndogenous MetaboliteVitamin DVitamin D receptorInhibitorinhibitorinhibit

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Product name:
Cholecalciferol
Cat. No.:
HY-15398
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