2. Disease Areas
  3. Inflammation or Immune System Disease
  4. Digestive System Inflammation
  5. Pancreatitis

Pancreatitis

Pancreatitis is inflammation of the pancreas, a vital gland located behind the stomach that produces digestive enzymes and hormones regulating blood sugar. It can manifest as acute pancreatitis, characterized by sudden onset and often caused by gallstones or alcohol abuse, or chronic pancreatitis, which develops over time due to prolonged inflammation, commonly linked to long-term alcohol use or genetic factors. Symptoms typically include severe upper abdominal pain radiating to the back, nausea, vomiting, fever, and abdominal tenderness. The condition may lead to serious complications such as pancreatic necrosis, pseudocysts, infection, bleeding, and diabetes if untreated. Management involves hospitalization for intravenous fluids, pain control, nutritional support, and addressing underlying causes. Early diagnosis and intervention are crucial to prevent progression and reduce mortality risk.

References:

Pancreatitis (10):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-16658B
    Z-VAD-FMK 161401-82-7 99.76%
    Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis.
    Z-VAD-FMK
  • HY-N2376
    Chrysin-7-O-glucuronide 35775-49-6 99.47%
    Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury.
    Chrysin-7-O-glucuronide
  • HY-181526
    Sim-9 3099101-40-0
    Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 (IRF3). Sim-9 binds covalently to the Cys222 residue of IRF3, induces its conformational change, blocks its interactions with TRIF, MAVS and STING, and inhibits IRF3 homodimerization and type I interferon response. Sim-9 exhibits significant anti-inflammatory, organ-protective and survival benefits in mouse models of sepsis and acute pancreatitis. Sim-9 can be used for research related to inflammatory diseases.
    Sim-9
  • HY-160789
    C3001a 2415154-29-7
    C3001a is a selective TREK-1 and TREK-2 channel activator with EC50 values of 12.81 μM and 11.31 μM, respectively. C3001a does not affect other two-pore domain K+ (K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a can be used for the study of pain and pancreatitis.
    C3001a
  • HY-183545
    sEH-IN-24 3121405-85-1
    sEH-IN-24 (Compound (+)-34) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.9 nM. sEH-IN-24 inhibits the pro-inflammatory cytokines TNF-α and IL-6. sEH-IN-24 exhibits anti-inflammatory effects and exerts analgesic activity in vivo. sEH-IN-24 prevents pancreatic edema, inflammation and parenchymal atrophy. sEH-IN-24 can be used for the research of acute pancreatitis.
    sEH-IN-24
  • HY-182692
    KMO-IN-1 1953156-92-7
    KMO-IN-1 is a KMO inhibitor with a mean pIC50 of 8.5 against KMO. KMO-IN-1 can be used in the research of acute pancreatitis.
    KMO-IN-1
  • HY-N0455C
    L-Arginine arginine 37466-21-0
    L-Arginine arginine is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis.
    L-Arginine arginine
  • HY-122692
    TRPV4/TRPA1-IN-1 1532515-60-8
    TRPV4/TRPA1-IN-1 is a TRPV4/TRPA1 inhibitor that suppresses TRPV4/TRPA1-mediated calcium influx. TRPV4/TRPA1-IN-1 alleviates pain behaviors in a mouse trigeminal stimulation pain model and inhibits inflammation and pain-related behaviors in a mouse acute pancreatitis model. TRPV4/TRPA1-IN-1 can be used in research on acute pancreatitis.
    TRPV4/TRPA1-IN-1
  • HY-153047
    Trypsin-IN-2 1984788-85-3
    Trypsin-IN-2 (Compound 12) is an efficient and highly selective inhibitor of human trypsin, with an IC₅₀ of 8 nM. Trypsin-IN-2 can be used for research on pancreatic cancer.
    Trypsin-IN-2
  • HY-W392413
    Glutathione monoethyl ester 118421-50-4
    Glutathione monoethyl ester is a glutathione derivative that can be transported into cells and hydrolyzed into glutathione. Glutathione monoethyl ester downregulates the gene expression of TEN1 and CTC1 while upregulating TERT expression. Glutathione monoethyl ester enhances telomerase activity, promotes proliferation and differentiation in aged bone marrow stromal cells, while elevating glutathione levels and reducing oxidative stress, protein aggregation and cell death in motor neuronal cells. Glutathione monoethyl ester confers broad multi-organ protection against cerebral ischemia, renal injury, liver damage, and pancreatitis. Glutathione monoethyl ester can be used for the research of amyotrophic lateral sclerosis, stroke, acute renal failure, liver injury, and acute pancreatitis.
    Glutathione monoethyl ester