118421-50-4
Chemical Structure
Glutathione monoethyl ester
- CAS No.: 118421-50-4
- Formula:C12H21N3O6S
- Molecular Weight:335.38
IUPAC Name: O-guanidinohomoserine compound with sulfuric acid (1:1)
InChIKey: RFHCUXJIPZTRBX-GEMLJDPKSA-N
SMILES: OC(CNC([C@H](CS)NC(CC[C@H](N)C(O)=O)=O)=O)=O.CCO
Biological Activity: Glutathione monoethyl ester is a glutathione derivative that can be transported into cells and hydrolyzed into glutathione. Glutathione monoethyl ester downregulates the gene expression of TEN1 and CTC1 while upregulating TERT expression. Glutathione monoethyl ester enhances telomerase activity, promotes proliferation and differentiation in aged bone marrow stromal cells, while elevating glutathione levels and reducing oxidative stress, protein aggregation and cell death in motor neuronal cells. Glutathione monoethyl ester confers broad multi-organ protection against cerebral ischemia, renal injury, liver damage, and pancreatitis. Glutathione monoethyl ester can be used for the research of amyotrophic lateral sclerosis, stroke, acute renal failure, liver injury, and acute pancreatitis[1][2][3][4][5][6].
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Glutathione monoethyl ester | Glutathione monoethyl ester is a glutathione derivative that can be transported into cells and hydrolyzed into glutathione. Glutathione monoethyl ester downregulates the gene expression of TEN1 and CTC1 while upregulating TERT expression. Glutathione monoethyl ester enhances telomerase activity, promotes proliferation and differentiation in aged bone marrow stromal cells, while elevating glutathione levels and reducing oxidative stress, protein aggregation and cell death in motor neuronal cells. Glutathione monoethyl ester confers broad multi-organ protection against cerebral ischemia, renal injury, liver damage, and pancreatitis. Glutathione monoethyl ester can be used for the research of amyotrophic lateral sclerosis, stroke, acute renal failure, liver injury, and acute pancreatitis. | |||||||||||||||||||||
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- [1]. Aminizadeh N, et al. Stimulation of cell proliferation by glutathione monoethyl ester in aged bone marrow stromal cells is associated with the assistance of TERT gene expression and telomerase activity. In Vitro Cell Dev Biol Anim. 2016;52(7):772-781. [Content Brief]
- [2]. Chen T. Glutathione monoethyl ester prevents TDP-43 pathology in motor neuronal NSC-34 cells. Neurochem Int. 2018;112:278-287.
- [3]. Anderson MF, et al. Glutathione monoethyl ester provides neuroprotection in a rat model of stroke. Neurosci Lett. 2004;354(2):163-165. [Content Brief]
- [4]. Houser MT, et al. Glutathione monoethyl ester moderates mercuric chloride-induced acute renal failure. Nephron. 1992;61(4):449-455. [Content Brief]
- [5]. Uedono Y, et al. Lipopolysaccharide-mediated hepatic glutathione depletion and progressive mitochondrial damage in mice: protective effect of glutathione monoethyl ester. J Surg Res. 1997;70(1):49-54. [Content Brief]
- [6]. Neuschwander-Tetri BA, et al. Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse. J Clin Invest. 1992;89(1):109-116. [Content Brief]
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