70858-45-6
Chemical Structure
Paucimannose
- CAS No.: 70858-45-6
- Formula:C34H58N2O26
- Molecular Weight:910.82
IUPAC Name: 5-bromo-4-methylthiophene-2-carboxamide
InChIKey: DJUIFTOHRFYXSA-YONMKSMASA-N
SMILES: OC[C@@H](O[C@H]([C@@H]([C@H]1O)NC(C)=O)O[C@H]([C@H](O)CO)[C@H](O)[C@H](C=O)NC(C)=O)[C@H]1O[C@H]2[C@H]([C@H]([C@@H]([C@H](O2)CO[C@H]3O[C@@H]([C@H]([C@@H]([C@@H]3O)O)O)CO)O)O[C@H]4O[C@@H]([C@H]([C@@H]([C@@H]4O)O)O)CO)O
Biological Activity: Paucimannose is a mannosidic N-glycan epitope. It acts as a carcinoembryonic antigen, and a marker for cancer, stem cell properties and inflammation. Paucimannose mainly exists in plants and invertebrates. It consists of oligomannose-type N-glycans that preferentially bind to mannose-binding lectin. Paucimannose localizes on the surface of resting cells and translocates upon cell activation. It can be used in studies related to Pseudomonas aeruginosa infection, cancer and pancreatitis[1][2][3].
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Paucimannose | Paucimannose is a mannosidic N-glycan epitope. It acts as a carcinoembryonic antigen, and a marker for cancer, stem cell properties and inflammation. Paucimannose mainly exists in plants and invertebrates. It consists of oligomannose-type N-glycans that preferentially bind to mannose-binding lectin. Paucimannose localizes on the surface of resting cells and translocates upon cell activation. It can be used in studies related to Pseudomonas aeruginosa infection, cancer and pancreatitis. | |||||||||||||||||||||
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- [1]. Loke I, et al. Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions. Mol Cell Proteomics. 2017 Aug;16(8):1507-1527. [Content Brief]
- [2]. Zipser B, et al. Mannitou monoclonal antibody uniquely recognizes paucimannose, a marker for human cancer, stemness, and inflammation[J]. Journal of Carbohydrate Chemistry, 2012, 31(4-6): 504-518.
- [3]. Dahmen AC, et al. Paucimannosidic glycoepitopes are functionally involved in proliferation of neural progenitor cells in the subventricular zone. Glycobiology. 2015;25(8):869-880. [Content Brief]
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