Paucimannose 

Paucimannose is a mannosidic N-glycan epitope. It acts as a carcinoembryonic antigen, and a marker for cancer, stem cell properties and inflammation. Paucimannose mainly exists in plants and invertebrates. It consists of oligomannose-type N-glycans that preferentially bind to mannose-binding lectin. Paucimannose localizes on the surface of resting cells and translocates upon cell activation. It can be used in studies related to Pseudomonas aeruginosa infection, cancer and pancreatitis^[1][2][3].

Paucimannose-enriched neutrophil elastase glycoforms exhibit preferential binding to mannose-binding lectin, with multivalent low-mannose structures showing the highest affinity, while sialylated glycoforms are excluded^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

910.82

C₃₄H₅₈N₂O₂₆

70858-45-6

Solid

White to off-white

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• [1]. Loke I, et al. Paucimannose-Rich N-glycosylation of Spatiotemporally Regulated Human Neutrophil Elastase Modulates Its Immune Functions. Mol Cell Proteomics. 2017 Aug;16(8):1507-1527.

  [2]. Zipser B, et al. Mannitou monoclonal antibody uniquely recognizes paucimannose, a marker for human cancer, stemness, and inflammation[J]. Journal of Carbohydrate Chemistry, 2012, 31(4-6): 504-518.

  [3]. Dahmen AC, et al. Paucimannosidic glycoepitopes are functionally involved in proliferation of neural progenitor cells in the subventricular zone. Glycobiology. 2015;25(8):869-880.  [Content Brief]