Pseudomonas Aeruginosa Infection

Pseudomonas aeruginosa pneumonia is a rare but severe lung infection that can present as primary pneumonia in intensive care settings without bacteremia or as bacteremic pneumonia, particularly in patients with neutropenia. It frequently affects individuals with cystic fibrosis, leading to recurrent chronic lower respiratory infections. Clinical manifestations include fever, chills, dyspnea, cyanosis, productive cough, and systemic toxicity. Radiological and pathological findings often reveal alveolar hemorrhage, necrosis, and cavity formation, all of which contribute to significant morbidity and mortality.

References:

[1]. Pneumonia Caused by Pseudomonas Aeruginosa Infection. malacards.

Pseudomonas Aeruginosa Infection (68):

Targets:	Bacterial (64) Antibiotic (13) Fungal (6) Endogenous Metabolite (5) Beta-lactamase (4) Amyloid-β (1) Apoptosis (4) Biochemical Assay Reagents (3) Cytochrome P450 (1) DNA/RNA Synthesis (3) Drug Derivative (2) Elastase (2) Environmental Pollutants (4) Fluorescent Dye (2) Insecticide (1) Integrin (1) MMP (1) Necroptosis (4) Parasite (1) Penicillin-binding protein (PBP) (1) Potassium Channel (2) Protein Arginine Deiminase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) Tie (1) Topoisomerase (2)

Targets:

Bacterial (64)

Antibiotic (13)

Fungal (6)

Endogenous Metabolite (5)

Beta-lactamase (4)

Amyloid-β (1)

Apoptosis (4)

Biochemical Assay Reagents (3)

Cytochrome P450 (1)

DNA/RNA Synthesis (3)

Drug Derivative (2)

Elastase (2)

Environmental Pollutants (4)

Fluorescent Dye (2)

Insecticide (1)

Integrin (1)

MMP (1)

Necroptosis (4)

Parasite (1)

Penicillin-binding protein (PBP) (1)

Potassium Channel (2)

Protein Arginine Deiminase (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (4)

Tie (1)

Topoisomerase (2)

Cat. No.	상품명	CAS No.	Purity	화학구조

HY-B1248

Chlorhexidine	55-56-1	99.60%
Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).

HY-19806A

Ceftolozane sulfate	936111-69-2	99.69%
Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. Ceftolozane binds to P. aeruginosa essential PBPs (1b, 1c, 2 and 3) with high affinity. Ceftolozane inhibits cell wall synthesis by binding the PBPs. Ceftolozane sulfate inhibits P. aeruginosa and Enterobacteriaceae.

HY-P2915

Protocatechuate 3,4-dioxygenase	9029-47-4
Protocatechuate 3,4-dioxygenase is a dioxygenase. Protocatechuate 3,4-dioxygenase belongs to the non-heme iron dioxygenase class. Protocatechuate 3,4-dioxygenase catalyzes the cleavage of the aromatic ring of 3,4-dihydroxybenzoate, attaching two atoms of molecular oxygen to the compound to generate β-carboxy-cis,cis-muconate. Protocatechuate 3,4-dioxygenase is a key enzyme in the β-ketoadipic acid pathway. It is found in marine bacteria associated with Roseobacter. Protocatechuate 3,4-dioxygenase can be isolated from Pseudomonas aeruginosa.

HY-B0608

Chlorhexidine digluconate (20% in water)	18472-51-0	99.45%
Chlorhexidine digluconate (20% in water) is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine digluconate (20% in water) binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine digluconate (20% in water) has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine digluconate (20% in water) can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).

HY-B1145

Chlorhexidine dihydrochloride	3697-42-5	99.83%
Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).

HY-182942

PV-DPD-19	3112321-20-4
PV-DPD-19 is an autoinducer-2 (AI-2) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMMs. In co-culture systems with Staphylococcus aureus, PV-DPD-19 decreases the production of pyocyanin and Elastase in Pseudomonas aeruginosa. PV-DPD-19 impairs the adhesion ability of Staphylococcus aureus to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of Pseudomonas aeruginosa (MBIC₅₀ = 27 μg/mL) and Staphylococcus aureus (MBIC₅₀ = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo Galleria mellonella larva models.

HY-N17734

2-Deethoxy-2-hydroxyphantomolin	821799-76-2
2-Deethoxy-2-hydroxyphantomolin, Germacranolide, is an Antifungal and Antibacterial agent. 2-Deethoxy-2-hydroxyphantomolin can be isolated from Elephantopus tomentosus Linn and E. mollis. 2-Deethoxy-2-hydroxyphantomolin is moderately active against Candida albicans (14 mm clearing zone) and slightly active against Escherichia coli (12 mm), Pseudomonas aeruginosa (12 mm), Bacillus subtilis (14 mm), and Trichophyton mentagrophytes (13 mm).

HY-175044

(±)14(15)-EET Ethanolamide	1469713-10-7
(±)14(15)-EET Ethanolamide ((±)14(15)-Epoxy eicosatrienoyl ethanolamide) is a fatty acid monoepoxide. (±)-14(15)-EET ethanolamide can be used in the research of Pseudomonas aeruginosa infections and respiratory diseases.

HY-B0441A

Tobramycin sulfate	49842-07-1	98.0%
Tobramycin (Nebramycin Factor 6) sulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin sulfate can be used to pneumonia research caused by Pseudomonas aeruginosa.

HY-P99649

Gremubamab	1800381-36-5
Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections.

HY-W041988

Fmoc-Glu-OMe	145038-49-9	99.74%
Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO₃) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds.

HY-A0248B

Polymyxin B2	34503-87-2	99.59%
Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis.

HY-W013699

Chlorhexidine diacetate	56-95-1	99.68%
Chlorhexidine diacetate is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine diacetate binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine diacetate has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine diacetate can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).

HY-B0915

Orbifloxacin	113617-63-3	99.66%
Orbifloxacin is an orally administrable Antibiotic. Orbifloxacin disrupts the replication and proliferation of Bacterial DNA, inhibits bacterial growth and exerts bactericidal activity. Orbifloxacin inhibits the growth of canine-derived E. coli and Pseudomonas aeruginosa isolates. Orbifloxacin is used in research related to bacterial infections.

HY-111521

Meropenem-vaborbactam	2031124-72-6
Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC₅₀ of 0.5 μg/mL and an MIC₉₀ of 8 μg/mL.

HY-N7097

Sulbenicillin disodium	28002-18-8	98.84%
Sulbenicillin disodium is a semisynthetic α-sulfonylbenzylpenicillin antibiotic. Sulbenicillin disodium exerts antibacterial activity against multiple gram-negative rods. Sulbenicillin disodium inhibits primary and secondary platelet aggregation, serotonin release from platelets, and platelet adherence via platelet surface coating. Sulbenicillin disodium can be used for the research of Pseudomonas aeruginosa, Pseudomonas maltophilia, and Pseudomonas cepacia infections.

HY-P4809

Polybia-MP1	872043-01-1	99.03%
Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers.

HY-W093378

Silver(I) sulfide	21548-73-2
Silver (I) sulfide is a biochemical reagent. Silver (I) sulfide nanoparticles exert Antibacterial effects against a variety of resistant bacteria, including Gram-positive and Gram-negative bacteria. Silver (I) sulfide can be used in the research of bacterial infections, such as infections caused by Staphylococcus aureus, Streptococcus agalactiae, Escherichia coli and Pseudomonas species.

HY-P99953

Rivabazumab	1627519-84-9	99%
Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV.

HY-N10631

Paucimannose	70858-45-6
Paucimannose is a mannosidic N-glycan epitope. It acts as a carcinoembryonic antigen, and a marker for cancer, stem cell properties and inflammation. Paucimannose mainly exists in plants and invertebrates. It consists of oligomannose-type N-glycans that preferentially bind to mannose-binding lectin. Paucimannose localizes on the surface of resting cells and translocates upon cell activation. It can be used in studies related to Pseudomonas aeruginosa infection, cancer and pancreatitis.

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