Tobramycin sulfate
Based on 18 publication(s) in Google Scholar
Tobramycin (Nebramycin Factor 6) sulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin sulfate can be used to pneumonia research caused by Pseudomonas aeruginosa.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 49842-07-1
- Formula: C18H37N5O9.5/2H2O4S
- Molecular Weight:712.18
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Publications Citing Use of MedChemExpress (MCE) Tobramycin sulfate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- MedComm (2020). 2025 Jan 8;6(1):e70046. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- NPJ Biofilms Microbiomes. 2025 Mar 7;11(1):40. [Abstract]
- Food Chem. 2023 Mar 1:403:134399. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Theriogenology. 2025 Jun:239:117374. [Abstract]
- Curr Microbiol. 2021 Dec 14;79(1):12. [Abstract]
- J Microbiol Methods. 2026 Feb 25:107441. [Abstract]
- Basic Clin Androl. 2025 Mar 7;35(1):9. [Abstract]
- bioRxiv. 2024 May 10.
- bioRxiv. 2024 Feb 9.
Customer Validation & Images
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Microbiological Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
All Antibiotic Isoforms
More
Biological Activity
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Aminoglycoside |
Tobramycin (0-50 ng/mL; 24 hours) sulfate combinates with mycobacterium fortuitum enzyme (PodA) can greatly decreases P. aeruginosa cell viability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tobramycin (s.c., single dose) sulfate LD50 values in mice and rats are 441 and 969 mg/kg, respectively[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine Model of Pseudomonas aeruginosa Pneumonia Female, Swiss-Webster mice [3]
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Dosage:50, 100, 150, 214, and 400 mg/kg/day
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Administration:Intraperitoneal injection (i.p.) ,once every 4h
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Result:Had near-maximal killing of the wild-type bacteria occurred at approximately 150 mg/kg/day when tobramycin alone.
Combinated with Meropenem (HY-13678) produced near-maximal effect (i.e., bacterial cell kill) at low doses of both drugs (60 and 50 mg/kg/day for Meropenem (HY-13678) and tobramycin, respectively).
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Animal Model:Mice, rats, cats and dogs for toxicologic evaluation[4]
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Dosage:7.5,15,30,120,441,969 mg/kg
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Administration:Subcutaneous injection (s.c.), Intravenous injection (i.v.) ,Intramuscular injection(i.m.)
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Result:The s.c. LD50 values in mice and rats were 441 and 969 mg/kg, respectively.
Within 1 hour after treated, death with central nervous system depression as a precursor occurred in rats and mice.
A 100 mg/kg iv dose in chloraloseanesthetized catsproduced a moderate, transient decreasein blood pressure and a significant decrease in inspiratory volume and soleus twitch force.
Changed renal tissue in rats which were given daily sc doses of 15-120 mg/kg for 3 months.
im dose of 7.5 mg/kg for a l-month had no apparent effect on dogs, but a 30 mg/kg dose for a l-month produced severerenal damage.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 49842-07-1
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Appearance Solid
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Molecular Weight 712.18
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Formula C18H37N5O9.5/2H2O4S
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Color White to off-white
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SMILES
O=S(O)(O)=O.OC[C@H]([C@@H](O)[C@H](N)[C@H]1O)O[C@]1([H])O[C@@H]2[C@H]([C@@H]([C@@H](N)C[C@H]2N)O[C@@]3([H])O[C@@H]([C@@H](O)C[C@H]3N)CN)O.[5/2]
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Synonyms
Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate
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Structure Classification
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Initial Source
Streptomyces tenebrarius
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (18)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
MedComm (2020)
Novel antibiotics against Staphylococcus aureus without detectable resistance by targeting proton motive force and FtsH. [Abstract]2025 Jan 8;6(1):e70046. PMID: 39781293
Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Jan 8;6(1):e70046. [Abstract]
Time-killing curves of drug combinations between STK848198 (0.5 µg/mL) and antibiotics with FICI≤ 0.5 [SM (8 µg/mL)/ Tobramycin (32 µg/mL)/ AMP (2 µg/mL)/ fosfomycin (0.5 µg/mL)/ SIS (32 µg/mL)/ gentamycin (8 µg/mL)].
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
NPJ Biofilms Microbiomes
Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates. [Abstract]2025 Mar 7;11(1):40. PMID: 40055321 -
Food Chem
Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. [Abstract]2023 Mar 1:403:134399. PMID: 36182859 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Int J Mol Sci
Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]2025 Feb 6;26(3):1381. PMID: 39941149 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
ACS Infect Dis
Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]2024 Apr 12;10(4):1327-1338. PMID: 38567846
Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Representative viable cell colony count was collected from the kidney and spleen.
Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in the spleen were quantified.
Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in kidneys were quantified.
Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Quantification of the inflammatory cytokine IL-6 in the serum.
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AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. Compound combinational activity between PVB and aminoglycosides, respectively. AMK, amikacin. GEN, gentamycin, KANA, kanamycin. TOB, Tobramycin (MICalone = 64 μg/mL; MICcombined = 256 μg/mL). SPC, spectinomycin.
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Theriogenology
Dual roles of the TLR2/TLR4/NLRP3-H-PGDS-PGD2 axis in regulating the inflammatory response in Escherichia coli-infected bovine bone marrow-derived macrophages and endometrial tissue. [Abstract]2025 Jun:239:117374. PMID: 40112766 -
Curr Microbiol
Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa. [Abstract]2021 Dec 14;79(1):12. PMID: 34905092 -
J Microbiol Methods
Comparison of agar-based and checkerboard methods to assess phage-antimicrobial synergy in Pseudomonas aeruginosa. [Abstract]2026 Feb 25:107441. PMID: 41759663 -
Basic Clin Androl
2025 Mar 7;35(1):9. PMID: 40055615 -
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Solvent & Solubility
H2O : 250 mg/mL (351.03 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Tobramycin. [Content Brief]
[2]. VanDrisse CM, et.al. Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2022012118. [Content Brief]
[3]. Louie A, et.al. Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia. Antimicrob Agents Chemother. 2013 Jun;57(6):2788-92. [Content Brief]
[4]. Welles JS, et.al. Preclinical toxicology studies with tobramycin. Toxicol Appl Pharmacol. 1973 Jul;25(3):398-409. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.4041 mL | 7.0207 mL | 14.0414 mL | 35.1035 mL |
| 5 mM | 0.2808 mL | 1.4041 mL | 2.8083 mL | 7.0207 mL | |
| 10 mM | 0.1404 mL | 0.7021 mL | 1.4041 mL | 3.5103 mL | |
| 15 mM | 0.0936 mL | 0.4680 mL | 0.9361 mL | 2.3402 mL | |
| 20 mM | 0.0702 mL | 0.3510 mL | 0.7021 mL | 1.7552 mL | |
| 25 mM | 0.0562 mL | 0.2808 mL | 0.5617 mL | 1.4041 mL | |
| 30 mM | 0.0468 mL | 0.2340 mL | 0.4680 mL | 1.1701 mL | |
| 40 mM | 0.0351 mL | 0.1755 mL | 0.3510 mL | 0.8776 mL | |
| 50 mM | 0.0281 mL | 0.1404 mL | 0.2808 mL | 0.7021 mL | |
| 60 mM | 0.0234 mL | 0.1170 mL | 0.2340 mL | 0.5851 mL | |
| 80 mM | 0.0176 mL | 0.0878 mL | 0.1755 mL | 0.4388 mL | |
| 100 mM | 0.0140 mL | 0.0702 mL | 0.1404 mL | 0.3510 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tobramycin sulfate Related Classifications
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