2. Anti-infection
  3. Bacterial Antibiotic
  4. Tobramycin sulfate

Tobramycin sulfate  (Synonyms: Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate)

Cat. No.: HY-B0441A Purity: 98.0%
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Tobramycin (Nebramycin Factor 6) sulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin sulfate can be used to pneumonia research caused by Pseudomonas aeruginosa.

For research use only. We do not sell to patients.

CAS No. : 49842-07-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
Solid
100 mg In-stock
500 mg In-stock
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Based on 16 publication(s) in Google Scholar

Other Forms of Tobramycin sulfate:

Tobramycin sulfate Related Antibodies

Top Publications Citing Use of Products

    Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Jan 8;6(1):e70046.  [Abstract]

    Time-killing curves of drug combinations between STK848198 (0.5 µg/mL) and antibiotics with FICI≤ 0.5 [SM (8 µg/mL)/ Tobramycin (32 µg/mL)/ AMP (2 µg/mL)/ fosfomycin (0.5 µg/mL)/ SIS (32 µg/mL)/ gentamycin (8 µg/mL)].

    Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141.  [Abstract]

    Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. Compound combinational activity between PVB and aminoglycosides, respectively. AMK, amikacin. GEN, gentamycin, KANA, kanamycin. TOB, Tobramycin (MICalone = 64 μg/mL; MICcombined = 256 μg/mL). SPC, spectinomycin.

    Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Representative viable cell colony count was collected from the kidney and spleen.

    Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in the spleen were quantified.

    Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in kidneys were quantified.

    Tobramycin sulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Quantification of the inflammatory cytokine IL-6 in the serum.

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    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    Tobramycin (Nebramycin Factor 6) sulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin sulfate can be used to pneumonia research caused by Pseudomonas aeruginosa[1][2][3][4].

    IC50 & Target

    Aminoglycoside

     

    In Vitro

    Tobramycin (0-50 ng/mL; 24 hours) sulfate combinates with mycobacterium fortuitum enzyme (PodA) can greatly decreases P. aeruginosa cell viability[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Tobramycin sulfate Related Antibodies
    In Vivo

    Tobramycin (50-400 mg/kg/day, i.p., once every 4h) sulfate combinates with Meropenem (HY-13678) produces bacterial cell kill effect at low doses of both drugs in murine pneumonia model. [3].
    Tobramycin (s.c., single dose) sulfate LD50 values in mice and rats are 441 and 969 mg/kg, respectively[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Murine Model of Pseudomonas aeruginosa Pneumonia Female, Swiss-Webster mice [3]
    Dosage: 50, 100, 150, 214, and 400 mg/kg/day
    Administration: Intraperitoneal injection (i.p.) ,once every 4h
    Result: Had near-maximal killing of the wild-type bacteria occurred at approximately 150 mg/kg/day when tobramycin alone.
    Combinated with Meropenem (HY-13678) produced near-maximal effect (i.e., bacterial cell kill) at low doses of both drugs (60 and 50 mg/kg/day for Meropenem (HY-13678) and tobramycin, respectively).
    Animal Model: Mice, rats, cats and dogs for toxicologic evaluation[4]
    Dosage: 7.5,15,30,120,441,969 mg/kg
    Administration: Subcutaneous injection (s.c.), Intravenous injection (i.v.) ,Intramuscular injection(i.m.)
    Result: The s.c. LD50 values in mice and rats were 441 and 969 mg/kg, respectively.
    Within 1 hour after treated, death with central nervous system depression as a precursor occurred in rats and mice.
    A 100 mg/kg iv dose in chloraloseanesthetized catsproduced a moderate, transient decreasein blood pressure and a significant decrease in inspiratory volume and soleus twitch force.
    Changed renal tissue in rats which were given daily sc doses of 15-120 mg/kg for 3 months.
    im dose of 7.5 mg/kg for a l-month had no apparent effect on dogs, but a 30 mg/kg dose for a l-month produced severerenal damage.
    Clinical Trial
    Molecular Weight

    712.18

    Formula

    C18H37N5O9.5/2H2O4S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(O)(O)=O.OC[C@H]([C@@H](O)[C@H](N)[C@H]1O)O[C@]1([H])O[C@@H]2[C@H]([C@@H]([C@@H](N)C[C@H]2N)O[C@@]3([H])O[C@@H]([C@@H](O)C[C@H]3N)CN)O.[5/2]
    Structure Classification
    Initial Source

    Streptomyces tenebrarius
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 250 mg/mL (351.03 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4041 mL 7.0207 mL 14.0414 mL
    5 mM 0.2808 mL 1.4041 mL 2.8083 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.4041 mL 7.0207 mL 14.0414 mL 35.1035 mL
    5 mM 0.2808 mL 1.4041 mL 2.8083 mL 7.0207 mL
    10 mM 0.1404 mL 0.7021 mL 1.4041 mL 3.5103 mL
    15 mM 0.0936 mL 0.4680 mL 0.9361 mL 2.3402 mL
    20 mM 0.0702 mL 0.3510 mL 0.7021 mL 1.7552 mL
    25 mM 0.0562 mL 0.2808 mL 0.5617 mL 1.4041 mL
    30 mM 0.0468 mL 0.2340 mL 0.4680 mL 1.1701 mL
    40 mM 0.0351 mL 0.1755 mL 0.3510 mL 0.8776 mL
    50 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7021 mL
    60 mM 0.0234 mL 0.1170 mL 0.2340 mL 0.5851 mL
    80 mM 0.0176 mL 0.0878 mL 0.1755 mL 0.4388 mL
    100 mM 0.0140 mL 0.0702 mL 0.1404 mL 0.3510 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Tobramycin sulfate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tobramycin49842-07-1Nebramycin Factor 6Deoxykanamycin BNebramycin Factor6Nebramycin Factor-6BacterialAntibioticInhibitorinhibitorinhibit

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