Meropenem  (Synonyms: SM 7338)

Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)^[1][2].

Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

383.46

C₁₇H₂₅N₃O₅S

96036-03-2

O=C(C(N12)=C(S[[email protected]@H]3CN[[email protected]](C(N(C)C)=O)C3)[[email protected]](C)[[email protected]]2([H])[[email protected]@H]([[email protected]](O)C)C1=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. L Slaney, et al. In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother. 1989 Sep;24 Suppl A:183-6.  [Content Brief]

  [2]. George G Zhanel, et al. Comparative review of the carbapenems. Drugs. 2007;67(7):1027-52.  [Content Brief]

  [3]. Umit Ateskan, et al. Deferoxamine and meropenem combination therapy in experimental acute pancreatitis. Pancreas. 2003 Oct;27(3):247-52.  [Content Brief]