Meropenem-d6
Based on 1 Customer Validation
Meropenem-d6 is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
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- Pureté: 98.25%
- CAS No.: 1217976-95-8
- Formule: C17H19D6N3O5S
- Masse moléculaire:389.50
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217976-95-8
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Unlabeled Cas 96036-03-2
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Appearance Solid
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Masse moléculaire 389.50
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Formule C17H19D6N3O5S
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Color Off-white to light yellow
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SMILES
[H][C@]12[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C(C(O)=O)N1C([C@]([C@@H](C)O)2[H])=O
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Synonyms
SM 7338-d6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
H2O : 100 mg/mL (256.74 mM; Need ultrasonic)
DMSO : 100 mg/mL (256.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. L Slaney, et al. In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother. 1989 Sep;24 Suppl A:183-6. [Content Brief]
[3]. George G Zhanel, et al. Comparative review of the carbapenems. Drugs. 2007;67(7):1027-52. [Content Brief]
[4]. Umit Ateskan, et al. Deferoxamine and meropenem combination therapy in experimental acute pancreatitis. Pancreas. 2003 Oct;27(3):247-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5674 mL | 12.8370 mL | 25.6739 mL | 64.1849 mL |
| 5 mM | 0.5135 mL | 2.5674 mL | 5.1348 mL | 12.8370 mL | |
| 10 mM | 0.2567 mL | 1.2837 mL | 2.5674 mL | 6.4185 mL | |
| 15 mM | 0.1712 mL | 0.8558 mL | 1.7116 mL | 4.2790 mL | |
| 20 mM | 0.1284 mL | 0.6418 mL | 1.2837 mL | 3.2092 mL | |
| 25 mM | 0.1027 mL | 0.5135 mL | 1.0270 mL | 2.5674 mL | |
| 30 mM | 0.0856 mL | 0.4279 mL | 0.8558 mL | 2.1395 mL | |
| 40 mM | 0.0642 mL | 0.3209 mL | 0.6418 mL | 1.6046 mL | |
| 50 mM | 0.0513 mL | 0.2567 mL | 0.5135 mL | 1.2837 mL | |
| 60 mM | 0.0428 mL | 0.2139 mL | 0.4279 mL | 1.0697 mL | |
| 80 mM | 0.0321 mL | 0.1605 mL | 0.3209 mL | 0.8023 mL | |
| 100 mM | 0.0257 mL | 0.1284 mL | 0.2567 mL | 0.6418 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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