Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals

  • Int J Antimicrob Agents. 2018 Aug;52(2):269-271. doi: 10.1016/j.ijantimicag.2018.03.009.
Matthew E Falagas  1 ,  Tilemachos Skalidis  2 ,  Konstantinos Z Vardakas  3 ,  Georgios L Voulgaris  4 ,  Georgios Papanikolaou  5 ,  Nicholas Legakis  2 ,  Hellenic TP-6076 Study Group
Affiliations
  • 1. Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Department of Medicine, Henry Dunant Hospital Center, Athens, Greece; Department of Medicine, Tufts University School of Medicine, Boston, MA, USA. Electronic address: [email protected].
  • 2. Central Laboratories, IASO Group Hospitals, Athens, Greece.
  • 3. Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Department of Medicine, Henry Dunant Hospital Center, Athens, Greece.
  • 4. Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Laboratory of Pharmacokinetics and Toxicology, Department of Pharmacy, 401 General Military Hospital, Athens, Greece.
  • 5. Bioprepare Microbiology, Athens, Greece.
PMID: 29559273 DOI: 10.1016/j.ijantimicag.2018.03.009
Abstract

TP-6076 is a synthetic fluorocycline Antibiotic that inhibits Bacterial protein synthesis. In this study, carbapenem-resistant Acinetobacter baumannii clinical isolates from 13 Greek hospitals were tested for susceptibility to TP-6076 and comparator Antibiotics. Broth microdilution plates were used to determine minimum inhibitory concentrations (MICs). A total of 121 non-duplicate A. baumannii isolates were tested. The MIC50 and MIC90 values of TP-6076 were 0.03 mg/L and 0.06 mg/L, respectively. Tigecycline was the second most active Antibiotic (MIC90, 2 mg/L), followed by minocycline (MIC90, 8 mg/L). TP-6076 exhibited MIC90 values that were one dilution lower against tigecycline- and minocycline-susceptible isolates than against resistant isolates. There was no difference in the MIC90 value for colistin-susceptible or -resistant isolates. In conclusion, TP-6076 exhibited greater antimicrobial activity in vitro against carbapenem-resistant A. baumannii than comparator Antibiotics.

Keywords
Carbapenem-resistant Acinetobacter baumannii; Extensively drug-resistant; Fluorocycline; Minocycline; Pandrug-resistant; Tigecycline.
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