1. Anti-infection
  2. Beta-lactamase Bacterial Antibiotic
  3. Avibactam sodium

Avibactam sodium  (Synonyms: NXL-104)

Cat. No.: HY-14879A Purity: 99.92%
COA Handling Instructions

Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.

For research use only. We do not sell to patients.

Avibactam sodium Chemical Structure

Avibactam sodium Chemical Structure

CAS No. : 1192491-61-4

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10 mM * 1 mL in DMSO
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Solid
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10 mg USD 96 In-stock
50 mg USD 156 In-stock
100 mg USD 228 In-stock
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Customer Review

Based on 57 publication(s) in Google Scholar

Other Forms of Avibactam sodium:

Top Publications Citing Use of Products

56 Publications Citing Use of MCE Avibactam sodium

Proliferation Assay

    Avibactam sodium purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936.  [Abstract]

    Total β-lactamase activity for bacterial lysates is measured using the chromogenic substrate nitrocefin, with or without Avibactam at 4 mg/L. (b) GR20263 hydrolysis activity of different bacterial lysates is determined with or without Avibactam at 4 mg/L.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

    IC50 & Target

    IC50: 5 nM (CTX-M-15), 8 nM (TEM-1)[1]

    In Vitro

    Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases[2].
    Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 blaKPC-2 positive and 1 of blaOXA-232 positive Klebsiella pneumonia growth with MIC50 and MIC90 for both 8 mg/L[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model[3].
    Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Six-week-old BALB/c mice (female), K. pneumoniae strain Y8 infection model[4]
    Dosage: 0.375 mg/g in combination with Ceftazidime
    Administration: Subcutaneous injection, 4 h post infection and given every 8 h for 10 days
    Result: 70% of infection group mice died within 4 days, and all mice in the PBS group died within 13 days. All treatment group mice survived at 10 days post infection with the antibiotic applied every 8 h, whereas 100% of mice in this group died within 4 days after the antibiotic treatment stopped. The spleen and liver of treatment group mice showed lower CFU counts, as compare with that of infected group.
    Clinical Trial
    Molecular Weight

    287.23

    Formula

    C7H10N3NaO6S

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (174.08 mM; Need ultrasonic)

    DMSO : ≥ 30 mg/mL (104.45 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4815 mL 17.4077 mL 34.8153 mL
    5 mM 0.6963 mL 3.4815 mL 6.9631 mL
    10 mM 0.3482 mL 1.7408 mL 3.4815 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 140 mg/mL (487.41 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% Saline

      Solubility: ≥ 2.75 mg/mL (9.57 mM); Clear solution

    • 3.

      Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.75 mg/mL (9.57 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (7.24 mM); Clear solution

    • 5.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (7.24 mM); Clear solution

    • 6.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (7.24 mM); Clear solution

    • 7.

      Add each solvent one by one:  1% DMSO    99% Saline

      Solubility: ≥ 0.55 mg/mL (1.91 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.92%

    References
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    Avibactam sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Avibactam sodium
    Cat. No.:
    HY-14879A
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