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Avibactam sodium hydrate

(Synonyms: NXL-104 hydrate; AVE1330A hydrate)
97 Cited Publications
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Based on 97 publication(s) in Google Scholar

Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.

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  • Pureté : 99.61%
  • CAS No.: 2938989-90-1
  • Formule: C7H12N3NaO7S
  • Masse moléculaire:305.24
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Avibactam sodium hydrate Chemical Structure
    Avibactam sodium hydrate Chemical Structure
  • Experimental Validation Results for Avibactam sodium hydrate
  • Experimental Validation Results for Avibactam sodium hydrate
  • Experimental Validation Results for Avibactam sodium hydrate
  • Experimental Validation Results for Avibactam sodium hydrate
  • Experimental Validation Results for Avibactam sodium hydrate
  • Experimental Validation Results for Avibactam sodium hydrate
  • Experimental Validation Results for Avibactam sodium hydrate
CAS No.: 2938989-90-1
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Bio/Physico-chemical AssayRT-PCRIn Vivo Efficacy StudyWBCell Proliferation/Viability Assay
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  • Avibactam sodium hydrate Chemical Structure
    Avibactam sodium hydrate Chemical Structure
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  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]

    Customer Validation
     SREBP2 target gene transcript levels after treatment with Avibactam (0.69 μM, 24 h) analyzed by qPCR. Actin Beta (ACTB) was used as a reference gene.

  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]

    Customer Validation
     S-acylation levels of SCAP in Huh7 cells treated with Avibactam (0.69 μM, 24 h).

  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Nov 9;43(11):114962. [Abstract]

    Customer Validation
     Protein levels of SCAP and its downstream target proteins in Huh7 cells following treatment with Avibactam (0.69 μM, 24 h).

  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2022 Sep 30;77(10):2803-2808. [Abstract]

    Customer Validation
     In vivo change in log10 cfu/thigh of each isolate treated with saline control, Ceftazidime 2 g IV q8h 2 h infusion HSR, Ceftazidime/Avibactam 2.5 g q8h 2 h infusion HSR or meropenem 2 g q8h 3 h infusion HSR for three P. aeruginosa with inserted GES β-lactamases. (a) PSA 2136, with inserted GES-1 (ESBL). (b) PSA 2137, with inserted GES-5 (carbapenemase). (c) PSA 2138, with inserted GES-15. P values in the boxes represent the results from one-way ANOVA; P values are presented if between-group differences were present. The x-axis describes the treatment HSR [MIC (mg/L), % fT>MIC]. CAZ, Ceftazidime; CAZ-AVI, Ceftazidime/Avibactam; MEM, meropenem.

  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: Biosens Bioelectron. 2021 Dec 1:193:113526. [Abstract]

    Customer Validation
     Avibactam sodium (AVI: 6.3-50 mg/L) in the presence or absence of 200 mg/L ceftriaxone and/or 0.8 U/L CTX-M-14.

  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: Biosens Bioelectron. 2021 Dec 1:193:113526. [Abstract]

    Customer Validation
     Analysis of mixed mock samples containing 0.8 U/L each of NDM-1/CTX-M-14 were incubated with penicillin, ceftriaxone, cefepime, cefoxitin or meropenem (200 mg/L) in the presence and absence of 25 mg/L Avibactam sodium (AVI) for 15 min, then the NDM-1/CTX-M-14 treated and untreated antibiotic samples were analyzed.

  • 1/16

    Avibactam sodium hydrate purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936. [Abstract]

    Customer Validation
     Total β-lactamase activity for bacterial lysates is measured using the chromogenic substrate nitrocefin, with or without Avibactam at 4 mg/L. (b) GR20263 hydrolysis activity of different bacterial lysates is determined with or without Avibactam at 4 mg/L.

  • Avibactam sodium hydrate