1. Anti-infection
  2. Bacterial

Ciprofloxacin 

Cat. No.: HY-B0356 Purity: 99.55%
Data Sheet SDS Handling Instructions

Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

For research use only. We do not sell to patients.
Ciprofloxacin Chemical Structure

Ciprofloxacin Chemical Structure

CAS No. : 85721-33-1

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

In Vivo

Ciprofloxacin (1 mg/L) induces GST activity, in contrast with inhibited GST and CAT of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. In a murine model of pneumonic plague, ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in humans following a 500 mg dose of oral ciprofloxacin. Intraperitoneal ciprofloxacin reduces the lung bacterial load compared to controls treated with intraperitoneal PBS[3].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02724046 Epicentre|Medecins Sans Frontieres, Netherlands Meningitis, Meningococcal April 22, 2017 Phase 4
NCT00992329 University of Maryland|Food and Drug Administration (FDA) Healthy January 2013 Phase 1
NCT02967341 Universitair Ziekenhuis Brussel Childhood Cancer|Neutropenia March 2016 Phase 4
NCT02773732 University of Florida Leukemia|Acute Myelogenous Leukemia|Acute Myeloid Leukemia December 16, 2016 Phase 1|Phase 2
NCT02961751 National Institute of Allergy and Infectious Diseases (NIAID) Gonorrhoea September 13, 2016
NCT01789203 The Methodist Hospital System BK Virus Infection January 2013 Phase 4
NCT00609973 University of North Carolina, Chapel Hill|Crohn's and Colitis Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Crohn's Disease May 2008 Phase 2
NCT01402947 Shire Healthy July 2011 Phase 1
NCT03150082 GlaxoSmithKline|Parexel Infections, Bacterial July 31, 2017 Phase 1
NCT01157819 Otic Pharma Otitis Externa|Otorhinolaryngologic Diseases|Ear Diseases|Otitis July 2010 Phase 2
NCT00910351 Bayer Pseudomonas Infection July 2009 Phase 1
NCT02661438 Bayer|Novartis Bronchiectasis|Pulmonary Disease, Chronic Obstructive January 2016
NCT00668044 Bayer Burns|Bacterial Infections November 2002 Phase 3
NCT02326103 Helsinki University Alcoholic Hepatitis|Alcoholic Cirrhosis April 2015 Early Phase 1
NCT00431028 Federal University of São Paulo Inflammation|Bacterial Infections September 2005 Phase 1|Phase 2
NCT01753115 Emergent BioSolutions|Department of Health and Human Services Anthrax December 2012 Phase 2
NCT02598362 University Hospital, Ghent|Universitair Ziekenhuis Brussel Urinary Tract Infection|Pyelonephritis April 2015 Phase 4
NCT00481689 Bayer Urinary Tract Infections May 2004 Phase 4
NCT00785980 Mutual Pharmaceutical Company, Inc. Healthy September 2008 Phase 1
NCT00930982 Bayer|Novartis Bronchiectasis June 2009 Phase 2
NCT01542801 Korea University|Sungkyunkwan University|Kyungpook National University|Soon Chun Hyang University Adverse Reaction to Other Drugs and Medicines August 2011 Phase 4
NCT00805558 Facultad Nacional de Salud Publica|Universidad de Antioquia Chronic Periodontitis February 2009 Phase 4
NCT01764841 Bayer|Novartis Bronchiectasis May 2, 2013 Phase 3
NCT00194532 University of Washington Urinary Tract Infection June 2005
NCT00741052 International Centre for Diarrhoeal Disease Research, Bangladesh Cholera July 2007 Phase 3
NCT01243437 Centers for Disease Control and Prevention|MRC/UVRI Uganda Research Unit on Aids|Ministry of Health, Uganda Plague December 2010 Phase 2
NCT02015507 Vertex Pharmaceuticals Incorporated Cystic Fibrosis January 2014 Phase 1
NCT01168895 Bayer Infection|Pulmonary Disease, Chronic Obstructive July 2010 Phase 1
NCT00872209 Otic Pharma Otitis Externa|Otorhinolaryngologic Diseases|Ear Diseases|Otitis May 2009 Phase 1|Phase 2
NCT01733966 Quanta Medical|Laboratoires Iprad-Vegebom Diverticular Sigmoïditis May 2010 Phase 3
NCT02304822 Guohua Zeng|The First Affiliated Hospital of Guangzhou Medical University Kidney Stones August 2014
NCT01803191 Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia|Hospital General Universitario Santa Lucía|Hospital General Universitario Los Arcos del Mar Menor Urinary Tract Infections August 2012 Phase 4
NCT00964561 PharmAthene, Inc.|National Institutes of Health (NIH)|Medarex|Quintiles, Inc.|Department of Health and Human Services Anthrax August 2009 Phase 1
NCT00736983 Foundation for Liver Research Crohn's Disease With Perianal Fistulas September 2008 Phase 3
NCT00840294 University of Chicago Elevated Prostate Specific Antigen January 2009 Phase 3
NCT03177720 Medical University of Vienna Pneumonia May 29, 2016 Phase 1
NCT00980876 Farmoquimica S.A.|Pharmagenix Projetos em Medicina Farmacêutica Ltda. Otitis Externa April 2012 Phase 3
NCT02252978 Wake Forest University Health Sciences|National Cancer Institute (NCI) Prostate Cancer December 2015 Phase 2
NCT01538667 Bayer Respiratory System April 2012 Phase 1
NCT02118909 Helsinn Healthcare SA Healthy Volunteers|Non-smokers May 2014 Phase 1
NCT00645788 Bayer|Novartis Cystic Fibrosis May 2008 Phase 2
NCT01515007 Aradigm Corporation|Grifols Therapeutics Inc. Non Cystic Fibrosis Bronchiectasis April 2014 Phase 3
NCT00722735 MerLion Pharmaceuticals GmbH Urinary Tract Infections October 2008 Phase 2
NCT00190151 Assistance Publique - Hôpitaux de Paris Healthy Volunteers September 2004
NCT01952444 Elusys Therapeutics Inhalational Anthrax October 2013 Phase 1
NCT02734732 Umeå University Prostate Infection April 2015 Phase 2
NCT00961038 Bayer|Novartis Pharmaceuticals Pulmonary Disease, Chronic Obstructive August 2009 Phase 1
NCT00142272 International Centre for Diarrhoeal Disease Research, Bangladesh|Bayer|NEMC Cholera May 2001 Phase 3
NCT02106832 Bayer|Novartis Bronchiectasis April 2014 Phase 3
NCT00650351 Mylan Pharmaceuticals Healthy October 2005 Phase 1
NCT00649155 Mylan Pharmaceuticals Healthy November 2005 Phase 1
NCT00649662 Mylan Pharmaceuticals Healthy October 2005 Phase 1
NCT01072942 Bayer Pulmonary Disease, Chronic Obstructive January 2010 Phase 1
NCT00889967 Aradigm Corporation Non-Cystic Fibrosis Bronchiectasis February 2010 Phase 2
NCT01772615 Hvidovre University Hospital Ulcerative Colitis May 2011 Phase 4
NCT01052298 Bayer|Novartis Disease, Pulmonary April 2009 Phase 1
NCT00761462 Bayer Infectious Diseases October 1999 Phase 3
NCT02458781 San Antonio Military Medical Center Small Intestinal Bacterial Overgrowth January 2015 Phase 4
NCT00668122 Bayer Urinary Tract Infection March 2004 Phase 3
NCT00676533 Bayer Urinary Tract Infection June 2003 Phase 4
NCT00598403 Tedec-Meiji Farma, S.A. Urinary Tract Infections November 2007 Phase 3
NCT00651586 Allergan Acute Bacterial Corneal Ulcers|Bacterial Keratitis October 2003 Phase 2
NCT00003824 Southwest Oncology Group|National Cancer Institute (NCI) Bladder Cancer April 1999 Phase 3
NCT00663806 Bayer Urinary Tract Infections February 2003 Phase 4
NCT00137787 Center for Supporting Hematology-Oncology Trials|Bayer Febrile Neutropenia April 2005 Phase 3
NCT01994642 Par Pharmaceutical, Inc.|Novum Pharmaceutical Research Services Otitis Media in Patients With Tympanostomy Tubes. November 2013 Phase 3
NCT02216071 Exela Pharma Sciences, LLC. Acute Otitis Externa July 2014 Phase 3
NCT01208922 Dr. Falk Pharma GmbH Traveler's Diarrhea October 2010 Phase 3
NCT01768663 Vertex Pharmaceuticals Incorporated Cystic Fibrosis January 2013 Phase 1
NCT00669994 Bayer Urinary Tract Infection July 2003 Phase 4
NCT00257699 Mount Sinai Hospital, Canada|Crohn's and Colitis Foundation Crohn's Disease May 2006 Phase 2
NCT01910155 Par Pharmaceutical, Inc.|Novum Pharmaceutical Research Services Otitis Externa July 2013 Phase 3
NCT02068846 University of North Carolina, Chapel Hill|National Institute of Dental and Craniofacial Research (NIDCR) HIV|Salivary Gland Disease|Benign Lymphoepithelial Lesion April 2014 Phase 3
NCT01265173 Korea University SBP|Liver Cirrhosis April 2007 Phase 4
NCT01344512 University Hospital, Bordeaux Pediatrics|Ceftazidime|Ciprofloxacin|Voriconazole June 2011
NCT00688272 GlaxoSmithKline Healthy Subjects|Purpura, Thrombocytopenic, Idiopathic June 2008 Phase 1
NCT01690559 Bayer Infection April 2010
NCT00670215 Bayer Bacterial Infections April 2004 Phase 3
NCT02300220 Imperial College London Chronic Obstructive Pulmonary Disease (COPD) June 2014 Phase 3
NCT01400750 Universitaire Ziekenhuizen Leuven Cystic Fibrosis August 2001 Phase 4
NCT02223338 Loma Linda University Bacterial Resistance October 2014
NCT00062231 European Organisation for Research and Treatment of Cancer - EORTC Chronic Myeloproliferative Disorders|Fever, Sweats, and Hot Flashes|Infection|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neutropenia|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific April 2002
NCT01873690 Lawson Health Research Institute|The Physicians' Services Incorporated Foundation Urolithiasis November 2013 Phase 3
NCT00000641 National Institute of Allergy and Infectious Diseases (NIAID) Mycobacterium Avium-intracellulare Infection|HIV Infections Phase 2
NCT00791505 University of Monastir Chronic Obstructive Pulmonary Disease|Sepsis|Antibiotics July 2002 Phase 3
NCT02423759 Mansoura University Benign Prostate Hyperplasia April 2015 Phase 4
NCT02173262 Ottawa Hospital Research Institute Breast Cancer August 2014
NCT00832286 National Institute of Allergy and Infectious Diseases (NIAID) Dysbacteriosis July 2009 Phase 1
NCT01783106 Royal Liverpool University Hospital|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom Crohn's Disease January 2013 Phase 2
NCT01929460 Kaiser Permanente Pancreatic Cysts January 2014
NCT00760032 Florencia Vargas-Vorackova|Laboratorios Senosiain, S.A. de C.V.|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Cirrhosis|Ascites|Infections Phase 4
NCT01561794 Bayer Pneumonia May 2012 Phase 3
NCT02600559 Otonomy, Inc. Otitis Media October 2015 Phase 3
NCT02247960 University of Rochester Prostate Cancer|Urinary Tract Infection|Clostridium Difficile July 2014
NCT00596453 Johns Hopkins University Prostate Infections January 2008 Phase 4
NCT00138411 National Institute of Allergy and Infectious Diseases (NIAID) Bacillus Anthracis (Anthrax) October 2005 Phase 1
NCT01888822 University of Roma La Sapienza Cholelithiasis June 2013 Phase 4
NCT02358993 University of Pennsylvania Urinary Tract Infections|Catheter-Related Infections December 2014
NCT02036528 Royer Biomedical, Inc. Diabetic Foot Ulcers January 2014 Phase 1|Phase 2
NCT00367913 British Thoracic Society Pulmonary Diseases March 1995 Phase 4
NCT02719158 Otonomy, Inc. Acute Otitis Media|AOMT February 2016 Phase 2
NCT00945802 Shire Acute Otitis Externa July 2009 Phase 3
NCT02816112 Ottawa Hospital Research Institute Early Stage Breast Cancer September 2016 Phase 4
NCT01124799 Tibotec Pharmaceuticals, Ireland Hepatitis C Virus July 2010 Phase 1
NCT01749605 University of Iowa Uncomplicated Bacterial Cystitis October 2010 Phase 4
NCT02620007 Assistance Publique - Hôpitaux de Paris Crohn Disease|Adherent-invasive E. Coli December 2015 Phase 2
NCT03045185 University of Leeds Tooth Injuries|Endodontically Treated Teeth January 1, 2013
NCT00097773 Seattle Children's Hospital|National Heart, Lung, and Blood Institute (NHLBI)|Cystic Fibrosis Foundation Therapeutics|CF Therapeutics Development Network Coordinating Center Cystic Fibrosis|Pulmonary Disease, Chronic Obstructive September 2004 Phase 2
NCT01928433 MerLion Pharmaceuticals GmbH Urinary Tract Infections|Acute Pyelonephritis December 2012 Phase 2
NCT03228108 Radboud University|ZonMw: The Netherlands Organisation for Health Research and Development Complication|Infection|Prostate Cancer October 2017 Phase 4
NCT00002850 Gary Morrow|National Cancer Institute (NCI)|Eastern Cooperative Oncology Group|University of Rochester Infection|Multiple Myeloma March 1997 Phase 3
NCT02375295 University of British Columbia Kidney Stones March 2015 Phase 4
NCT02801370 Otonomy, Inc. Acute Otitis Externa|Swimmer's Ear June 2016 Phase 3
NCT02357407 Rennes University Hospital Infection June 2015 Phase 4
NCT01670435 Bayer Infection May 2007
NCT02011841 Seoul National University Hospital Spontaneous Bacterial Peritonitis January 2014 Phase 3
NCT02555059 Bayer Cystitis / Pyelonephritis / Cystic Fibrosis / Anthrax July 15, 2016
NCT02511561 Otonomy, Inc. Otitis Externa July 2015 Phase 2
NCT01659866 Northwestern University Infection August 2012 Phase 4
NCT01729195 Turku University Hospital|Tampere University of Technology Ankle Fracture March 2006 Phase 2
NCT02261896 Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau Pancreatic Cystic Lesion October 2014 Phase 4
NCT00961675 Shire Acute Otitis Externa August 2009 Phase 3
NCT00809913 Leiden University Medical Center|Bronovo Hospital|Medical Center Haaglanden|Spaarne Gasthuis|Rijnland Hospital|Diaconessenhuis Leiden|Groene Hart Ziekenhuis Urinary Tract Infection December 2008 Phase 4
NCT02790138 Takeda Colitis, Ulcerative October 12, 2016 Phase 4
NCT02340182 W.J. Wiersinga, MD, PhD|ZonMw: The Netherlands Organisation for Health Research and Development|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Healthy|Sepsis March 2013
NCT00719056 University of Athens|KAT Hospital of Athens Total Hip and Knee Arthroplasties August 2004 Phase 4
NCT00873626 Assistance Publique - Hôpitaux de Paris Urinary Tract Infection|Fever June 2009 Phase 4
NCT02127749 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Endotoxemia June 2014
NCT01027494 Alcon Research Acute Otitis Media December 2009 Phase 3
NCT02947763 Cairo University Periapical Periodontitis November 2016 Phase 1
NCT01386593 University Hospital, Basel, Switzerland Metabolic Detoxication, Phase I May 2011 Phase 1
NCT00214331 University of Wisconsin, Madison|Food and Drug Administration (FDA) Pregnancy April 2003 Phase 4
NCT00654108 National Institute of Allergy and Infectious Diseases (NIAID) Escherichia Coli Infections June 2008 Phase 1
NCT01723150 National University Hospital, Singapore|Tan Tock Seng Hospital|Singapore General Hospital Liver Abscess, Pyogenic November 5, 2013
NCT03027635 Nina Kimer|Copenhagen University Hospital, Hvidovre Cirrhosis|Ascites Hepatic|Ascites (Non-Malignant) December 2016
NCT02800785 University of Washington|Patient-Centered Outcomes Research Institute Appendicitis May 2016
NCT01908803 Alcon Research Acute Otitis Media December 2013 Phase 2
NCT01108601 McGill University Health Center Hearing Loss April 2008 Phase 1|Phase 2
NCT02168816 Loyola University Osteomyelitis June 2014 Phase 2
NCT01519310 The Cleveland Clinic Nutrition April 2010 Early Phase 1
NCT01785641 Chulalongkorn University Peritonitis December 2012
NCT00139230 Dana-Farber Cancer Institute|Brigham and Women's Hospital|Massachusetts General Hospital|Sanofi Squamous Cell Carcinoma|Carcinoma of Head/Neck January 1997 Phase 2
NCT01599806 AstraZeneca|Forest Laboratories Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis October 2012 Phase 3
NCT01595438 AstraZeneca|Forest Laboratories Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis October 2012 Phase 3
NCT01649635 Sanofi Prostate Cancer July 2012 Phase 4
NCT00392275 Indiana University School of Medicine|Indiana University Cataract November 2002 Phase 4
NCT02114671 Boehringer Ingelheim Healthy April 2014 Phase 1
NCT00294749 Poitiers University Hospital Men Who Must Undergo a Prostate Biopsy Related to Prostate Cancer Suspicion. February 2006 Phase 3
NCT01279252 King's College Hospital NHS Trust Chronic Lymphocytic Leukaemia (CLL) July 2011 Phase 2
NCT02532192 M.D. Anderson Cancer Center|Spectrum Pharmaceuticals, Inc Lymphoma December 2015 Phase 1
NCT00126698 St. Antonius Hospital Urinary Tract Infection|Bacteriuria January 2005 Phase 4
NCT02765256 University of Pennsylvania|Children's Hospital of Philadelphia|Crohn's and Colitis Foundation Crohn's Disease August 2016 Phase 2
NCT02196740 Lin Jiacheng|Sun Yat-sen University Periapical Diseases June 2013
NCT01137903 Universidad Complutense de Madrid Osteomyelitis|Diabetic Foot|Diabetic Foot Ulcers April 2010
NCT01059890 Poitiers University Hospital Bacterial Infection|Brain Injury September 2009 Phase 1
NCT02944825 University of California, San Diego|Genesis HealthCare Urolithiasis|UTI January 2016
NCT02717871 University Hospital, Geneva Keratitis; Infectious Disease (Manifestation) March 2016 Phase 3
NCT03012360 University Hospital, Lille|Ministry of Health, France Mechanical Ventilation Complication|Critical Illness September 2017 Phase 4
NCT00438269 Canadian Critical Care Trials Group|The Physicians' Services Incorporated Foundation Nosocomial Infection|Pneumonia|Systemic Inflammatory Response Syndrome|Critical Illness|Pyrexia February 2003 Phase 2
NCT01505634 Merck Sharp & Dohme Corp. Urinary Tract Infections|Pyelonephritis May 2012 Phase 2
NCT00107081 Swiss Pediatric Oncology Group|Swiss Cancer League|Bayer|GlaxoSmithKline Fever|Neutropenia|Cancer January 2004 Phase 3
NCT02829060 University of California, San Diego Nephrolithiasis|Urinary Tract Infection (UTI)|Sepsis January 2016
NCT03173053 Radboud University|ZonMw: The Netherlands Organisation for Health Research and Development|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Aalborg Universitetshospital|Rigshospitalet, Denmark Staphylococcus Aureus|Motility Disorder August 1, 2017
NCT00590785 Memorial Sloan Kettering Cancer Center|Cancer and Leukemia Group B High Risk|Breast Cancer|Positive Nodes|Cyclophosphamide|Doxorubicin August 13, 1996 Phase 3
NCT00445497 Clatterbridge Centre for Oncology|National Cancer Institute (NCI) Brain and Central Nervous System Tumors|Lymphoma|Neutropenia|Psychosocial Effects of Cancer and Its Treatment|Small Intestine Cancer|Unspecified Adult Solid Tumor, Protocol Specific July 2007 Phase 3
NCT00004216 Vion Pharmaceuticals|National Cancer Institute (NCI) Unspecified Adult Solid Tumor, Protocol Specific August 1999 Phase 1
NCT00355602 University of Dundee|Tenovus Scotland Colitis, Ulcerative July 2006
NCT00153634 Seattle Children's Hospital|Cystic Fibrosis Foundation Therapeutics Cystic Fibrosis|Chronic Bronchitis March 2004
NCT02724046 Epicentre|Medecins Sans Frontieres, Netherlands Meningitis, Meningococcal April 22, 2017 Phase 4
NCT00992329 University of Maryland|Food and Drug Administration (FDA) Healthy January 2013 Phase 1
NCT02967341 Universitair Ziekenhuis Brussel Childhood Cancer|Neutropenia March 2016 Phase 4
NCT02773732 University of Florida Leukemia|Acute Myelogenous Leukemia|Acute Myeloid Leukemia December 16, 2016 Phase 1|Phase 2
NCT02961751 National Institute of Allergy and Infectious Diseases (NIAID) Gonorrhoea September 13, 2016
NCT01789203 The Methodist Hospital System BK Virus Infection January 2013 Phase 4
NCT00609973 University of North Carolina, Chapel Hill|Crohn's and Colitis Foundation|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Crohn's Disease May 2008 Phase 2
NCT01402947 Shire Healthy July 2011 Phase 1
NCT03150082 GlaxoSmithKline|Parexel Infections, Bacterial July 31, 2017 Phase 1
NCT01157819 Otic Pharma Otitis Externa|Otorhinolaryngologic Diseases|Ear Diseases|Otitis July 2010 Phase 2
NCT00910351 Bayer Pseudomonas Infection July 2009 Phase 1
NCT02661438 Bayer|Novartis Bronchiectasis|Pulmonary Disease, Chronic Obstructive January 2016
NCT00668044 Bayer Burns|Bacterial Infections November 2002 Phase 3
NCT02326103 Helsinki University Alcoholic Hepatitis|Alcoholic Cirrhosis April 2015 Early Phase 1
NCT00431028 Federal University of São Paulo Inflammation|Bacterial Infections September 2005 Phase 1|Phase 2
NCT01753115 Emergent BioSolutions|Department of Health and Human Services Anthrax December 2012 Phase 2
NCT02598362 University Hospital, Ghent|Universitair Ziekenhuis Brussel Urinary Tract Infection|Pyelonephritis April 2015 Phase 4
NCT00481689 Bayer Urinary Tract Infections May 2004 Phase 4
NCT00785980 Mutual Pharmaceutical Company, Inc. Healthy September 2008 Phase 1
NCT00930982 Bayer|Novartis Bronchiectasis June 2009 Phase 2
NCT01542801 Korea University|Sungkyunkwan University|Kyungpook National University|Soon Chun Hyang University Adverse Reaction to Other Drugs and Medicines August 2011 Phase 4
NCT00805558 Facultad Nacional de Salud Publica|Universidad de Antioquia Chronic Periodontitis February 2009 Phase 4
NCT01764841 Bayer|Novartis Bronchiectasis May 2, 2013 Phase 3
NCT00194532 University of Washington Urinary Tract Infection June 2005
NCT00741052 International Centre for Diarrhoeal Disease Research, Bangladesh Cholera July 2007 Phase 3
NCT01243437 Centers for Disease Control and Prevention|MRC/UVRI Uganda Research Unit on Aids|Ministry of Health, Uganda Plague December 2010 Phase 2
NCT02015507 Vertex Pharmaceuticals Incorporated Cystic Fibrosis January 2014 Phase 1
NCT01168895 Bayer Infection|Pulmonary Disease, Chronic Obstructive July 2010 Phase 1
NCT00872209 Otic Pharma Otitis Externa|Otorhinolaryngologic Diseases|Ear Diseases|Otitis May 2009 Phase 1|Phase 2
NCT01733966 Quanta Medical|Laboratoires Iprad-Vegebom Diverticular Sigmoïditis May 2010 Phase 3
NCT02304822 Guohua Zeng|The First Affiliated Hospital of Guangzhou Medical University Kidney Stones August 2014
NCT01803191 Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia|Hospital General Universitario Santa Lucía|Hospital General Universitario Los Arcos del Mar Menor Urinary Tract Infections August 2012 Phase 4
NCT00964561 PharmAthene, Inc.|National Institutes of Health (NIH)|Medarex|Quintiles, Inc.|Department of Health and Human Services Anthrax August 2009 Phase 1
NCT00736983 Foundation for Liver Research Crohn's Disease With Perianal Fistulas September 2008 Phase 3
NCT00840294 University of Chicago Elevated Prostate Specific Antigen January 2009 Phase 3
NCT03177720 Medical University of Vienna Pneumonia May 29, 2016 Phase 1
NCT00980876 Farmoquimica S.A.|Pharmagenix Projetos em Medicina Farmacêutica Ltda. Otitis Externa April 2012 Phase 3
NCT02252978 Wake Forest University Health Sciences|National Cancer Institute (NCI) Prostate Cancer December 2015 Phase 2
NCT01538667 Bayer Respiratory System April 2012 Phase 1
NCT02118909 Helsinn Healthcare SA Healthy Volunteers|Non-smokers May 2014 Phase 1
NCT00645788 Bayer|Novartis Cystic Fibrosis May 2008 Phase 2
NCT01515007 Aradigm Corporation|Grifols Therapeutics Inc. Non Cystic Fibrosis Bronchiectasis April 2014 Phase 3
NCT00722735 MerLion Pharmaceuticals GmbH Urinary Tract Infections October 2008 Phase 2
NCT00190151 Assistance Publique - Hôpitaux de Paris Healthy Volunteers September 2004
NCT01952444 Elusys Therapeutics Inhalational Anthrax October 2013 Phase 1
NCT02734732 Umeå University Prostate Infection April 2015 Phase 2
NCT00961038 Bayer|Novartis Pharmaceuticals Pulmonary Disease, Chronic Obstructive August 2009 Phase 1
NCT00142272 International Centre for Diarrhoeal Disease Research, Bangladesh|Bayer|NEMC Cholera May 2001 Phase 3
NCT02106832 Bayer|Novartis Bronchiectasis April 2014 Phase 3
NCT00650351 Mylan Pharmaceuticals Healthy October 2005 Phase 1
NCT00649155 Mylan Pharmaceuticals Healthy November 2005 Phase 1
NCT00649662 Mylan Pharmaceuticals Healthy October 2005 Phase 1
NCT01072942 Bayer Pulmonary Disease, Chronic Obstructive January 2010 Phase 1
NCT00889967 Aradigm Corporation Non-Cystic Fibrosis Bronchiectasis February 2010 Phase 2
NCT01772615 Hvidovre University Hospital Ulcerative Colitis May 2011 Phase 4
NCT01052298 Bayer|Novartis Disease, Pulmonary April 2009 Phase 1
NCT00761462 Bayer Infectious Diseases October 1999 Phase 3
NCT02458781 San Antonio Military Medical Center Small Intestinal Bacterial Overgrowth January 2015 Phase 4
NCT00668122 Bayer Urinary Tract Infection March 2004 Phase 3
NCT00676533 Bayer Urinary Tract Infection June 2003 Phase 4
NCT00598403 Tedec-Meiji Farma, S.A. Urinary Tract Infections November 2007 Phase 3
NCT00651586 Allergan Acute Bacterial Corneal Ulcers|Bacterial Keratitis October 2003 Phase 2
NCT00003824 Southwest Oncology Group|National Cancer Institute (NCI) Bladder Cancer April 1999 Phase 3
NCT00663806 Bayer Urinary Tract Infections February 2003 Phase 4
NCT00137787 Center for Supporting Hematology-Oncology Trials|Bayer Febrile Neutropenia April 2005 Phase 3
NCT01994642 Par Pharmaceutical, Inc.|Novum Pharmaceutical Research Services Otitis Media in Patients With Tympanostomy Tubes. November 2013 Phase 3
NCT02216071 Exela Pharma Sciences, LLC. Acute Otitis Externa July 2014 Phase 3
NCT01208922 Dr. Falk Pharma GmbH Traveler's Diarrhea October 2010 Phase 3
NCT01768663 Vertex Pharmaceuticals Incorporated Cystic Fibrosis January 2013 Phase 1
NCT00669994 Bayer Urinary Tract Infection July 2003 Phase 4
NCT00257699 Mount Sinai Hospital, Canada|Crohn's and Colitis Foundation Crohn's Disease May 2006 Phase 2
NCT01910155 Par Pharmaceutical, Inc.|Novum Pharmaceutical Research Services Otitis Externa July 2013 Phase 3
NCT02068846 University of North Carolina, Chapel Hill|National Institute of Dental and Craniofacial Research (NIDCR) HIV|Salivary Gland Disease|Benign Lymphoepithelial Lesion April 2014 Phase 3
NCT01265173 Korea University SBP|Liver Cirrhosis April 2007 Phase 4
NCT01344512 University Hospital, Bordeaux Pediatrics|Ceftazidime|Ciprofloxacin|Voriconazole June 2011
NCT00688272 GlaxoSmithKline Healthy Subjects|Purpura, Thrombocytopenic, Idiopathic June 2008 Phase 1
NCT01690559 Bayer Infection April 2010
NCT00670215 Bayer Bacterial Infections April 2004 Phase 3
NCT02300220 Imperial College London Chronic Obstructive Pulmonary Disease (COPD) June 2014 Phase 3
NCT01400750 Universitaire Ziekenhuizen Leuven Cystic Fibrosis August 2001 Phase 4
NCT02223338 Loma Linda University Bacterial Resistance October 2014
NCT00062231 European Organisation for Research and Treatment of Cancer - EORTC Chronic Myeloproliferative Disorders|Fever, Sweats, and Hot Flashes|Infection|Leukemia|Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm|Myelodysplastic Syndromes|Myelodysplastic/Myeloproliferative Neoplasms|Neutropenia|Precancerous Condition|Unspecified Adult Solid Tumor, Protocol Specific April 2002
NCT01873690 Lawson Health Research Institute|The Physicians' Services Incorporated Foundation Urolithiasis November 2013 Phase 3
NCT00000641 National Institute of Allergy and Infectious Diseases (NIAID) Mycobacterium Avium-intracellulare Infection|HIV Infections Phase 2
NCT00791505 University of Monastir Chronic Obstructive Pulmonary Disease|Sepsis|Antibiotics July 2002 Phase 3
NCT02423759 Mansoura University Benign Prostate Hyperplasia April 2015 Phase 4
NCT02173262 Ottawa Hospital Research Institute Breast Cancer August 2014
NCT00832286 National Institute of Allergy and Infectious Diseases (NIAID) Dysbacteriosis July 2009 Phase 1
NCT01783106 Royal Liverpool University Hospital|National Association for Colitis and Crohn's Disease|National Institute for Health Research, United Kingdom Crohn's Disease January 2013 Phase 2
NCT01929460 Kaiser Permanente Pancreatic Cysts January 2014
NCT00760032 Florencia Vargas-Vorackova|Laboratorios Senosiain, S.A. de C.V.|Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Cirrhosis|Ascites|Infections Phase 4
NCT01561794 Bayer Pneumonia May 2012 Phase 3
NCT02600559 Otonomy, Inc. Otitis Media October 2015 Phase 3
NCT02247960 University of Rochester Prostate Cancer|Urinary Tract Infection|Clostridium Difficile July 2014
NCT00596453 Johns Hopkins University Prostate Infections January 2008 Phase 4
NCT00138411 National Institute of Allergy and Infectious Diseases (NIAID) Bacillus Anthracis (Anthrax) October 2005 Phase 1
NCT01888822 University of Roma La Sapienza Cholelithiasis June 2013 Phase 4
NCT02358993 University of Pennsylvania Urinary Tract Infections|Catheter-Related Infections December 2014
NCT02036528 Royer Biomedical, Inc. Diabetic Foot Ulcers January 2014 Phase 1|Phase 2
NCT00367913 British Thoracic Society Pulmonary Diseases March 1995 Phase 4
NCT02719158 Otonomy, Inc. Acute Otitis Media|AOMT February 2016 Phase 2
NCT00945802 Shire Acute Otitis Externa July 2009 Phase 3
NCT02816112 Ottawa Hospital Research Institute Early Stage Breast Cancer September 2016 Phase 4
NCT01124799 Tibotec Pharmaceuticals, Ireland Hepatitis C Virus July 2010 Phase 1
NCT01749605 University of Iowa Uncomplicated Bacterial Cystitis October 2010 Phase 4
NCT02620007 Assistance Publique - Hôpitaux de Paris Crohn Disease|Adherent-invasive E. Coli December 2015 Phase 2
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 3.0180 mL 15.0902 mL 30.1805 mL
5 mM 0.6036 mL 3.0180 mL 6.0361 mL
10 mM 0.3018 mL 1.5090 mL 3.0180 mL
Animal Administration
[3]

Female BALB/cAnNCrl (BALB/c) mice, 8-10 weeks old and 20 g (±4 g) are used in this assay. A single dose of ciprofloxacin (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following ciprofloxacin administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of ciprofloxacin and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of ciprofloxacin in the lung samples at 1 min post-administration. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

331.34

Formula

C₁₇H₁₈FN₃O₃

CAS No.

85721-33-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: < 0.1 mg/mL; Acetic acid: ≥ 165 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ciprofloxacin
Cat. No.:
HY-B0356
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