2. Cell Cycle/DNA Damage Apoptosis Anti-infection Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Topoisomerase Apoptosis Antibiotic Bacterial Mitochondrial Metabolism Reactive Oxygen Species (ROS)
  4. Ciprofloxacin lactate

Ciprofloxacin lactate  (Synonyms: Bay-09867 lactate)

Cat. No.: HY-W040298
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Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

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CAS No. : 97867-33-9

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Ciprofloxacin lactate Related Antibodies

Top Publications Citing Use of Products

46 Publications Citing Use of MCE Ciprofloxacin lactate

Bio/Physico-chemical Assay
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2D/3D Cell Culture and Differentiation
Flow Cytometry

    Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885.  [Abstract]

    Ciprofloxacin (CIP, 3 or 8 μg/L, 0-7 days) caused concentration-dependent damage in M. aeruginosa cells.

    Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885.  [Abstract]

    Ciprofloxacin (CIP, 3 or 8 μg/L, 3 or 7 days) increased the release and decreased the biosynthesis of MC-LR in M. aeruginosa cells.

    Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885.  [Abstract]

    Ciprofloxacin (CIP, 8 μg/L, 1 day) enriched gene ontology terms related to PSI in M. aeruginosa cells.

    Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885.  [Abstract]

    Ciprofloxacin (CIP, 3 or 8 μg/L, 21 days) induced continuous cell lysis, with maximum lytic rates of ∼70% compared to the initial cell density.

    Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885.  [Abstract]

    Ciprofloxacin (CIP, 3 or 8 μg/L, 1, 3, 5, or 7 days) induced cell death in M. aeruginosa.

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    Description

    Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].

    IC50 & Target

    Quinolone

     

    In Vitro

    Ciprofloxacin (Bay-09867) lactate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[1].
    Ciprofloxacin (Bay-09867) lactate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ciprofloxacin lactate Related Antibodies

    Cell Cycle Analysis[1]

    Cell Line: Tendon cells
    Concentration: 5, 10, 20 and 50 μg/mL
    Incubation Time: 24 hours
    Result: Decreased the cellularity of tendon cells.

    Apoptosis Analysis[1]

    Cell Line: Tendon cells
    Concentration: 50 μg/mL
    Incubation Time: 24 hours
    Result: Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.

    Western Blot Analysis[1]

    Cell Line: Tendon cells
    Concentration: 50 μg/mL
    Incubation Time: 0, 6, 12, 17 and 24 hours
    Result: Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulated the expression of PLK-1 protein.
    In Vivo

    Ciprofloxacin (Bay-09867) lactate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague[3].
    Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4].
    Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c mice[3]
    Dosage: 30 mg/kg
    Administration: Intraperitoneal injection; for 24 hours
    Result: Reduced the lung bacterial load in murine model of pneumonic plague.
    Animal Model: C57BL/6J mice[4]
    Dosage: 100 mg/kg
    Administration: Oral gavage; daily, for 4 weeks
    Result: Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
    Animal Model: C57BL/6J mice[4]
    Dosage: 100 mg/kg
    Administration: Oral gavage; daily, for 4 weeks
    Result: Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
    Clinical Trial
    Molecular Weight

    421.42

    Formula

    C20H24FN3O6
    CAS No.
    SMILES

    O=C(C1=CN(C2CC2)C3=CC(N4CCNCC4)=C(C=C3C1=O)F)O.OC(C(O)=O)C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Ciprofloxacin lactate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ciprofloxacin97867-33-9Bay-09867Bay09867Bay 09867TopoisomeraseApoptosisAntibioticBacterialMitochondrial MetabolismReactive Oxygen Species (ROS)mitochondrialDNADNA damageanti-proliferativeantibioticROSInhibitorinhibitorinhibit

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