Ciprofloxacin lactate
Based on 46 publication(s) in Google Scholar
Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.
For research use only. We do not sell to patients.
- CAS No.: 97867-33-9
- Formula: C20H24FN3O6
- Molecular Weight:421.42
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Publications Citing Use of MedChemExpress (MCE) Ciprofloxacin lactate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nature. 2024 Aug;632(8027):1137-1144. [Abstract]
- Nat Cell Biol. 2024 Sep;26(9):1545-1557. [Abstract]
- Adv Sci (Weinh). 2020 Jul 21;7(17):2001374. [Abstract]
- Water Res. 2024 Nov 29:271:122885. [Abstract]
- Water Res. 2023 Jul 15:240:120110. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Genome Biol. 2023 Apr 30;24(1):98. [Abstract]
- NPJ Biofilms Microbiomes. 2024 Oct 28;10(1):111. [Abstract]
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
- Emerg Contam. 2026 Feb 23.
- J Med Chem. 2025 Dec 11;68(23):25274-25289. [Abstract]
- J Agric Food Chem. 2025 Dec 23. [Abstract]
- Anal Chim Acta. 2022 Aug 15:1221:340082. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Virulence. 2024 Dec;15(1):2415952. [Abstract]
- Arab J Chem. 2024 May, 17, 5, 105745.
- PLoS Pathog. 2024 Dec 31;20(12):e1012783. [Abstract]
- Molecules. 2023 Jun 8;28(12):4628. [Abstract]
- Int J Antimicrob Agents. 2018 Aug;52(2):269-271. [Abstract]
- Antimicrob Agents Chemother. 2026 Apr;70(4):e0170625. [Abstract]
- Antimicrob Agents Chemother. 2025 May 23:e0024925. [Abstract]
- Front Microbiol. 2022 Feb 16:12:773664. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- iScience. 2023 Oct 7;26(11):108158. [Abstract]
- Microbiol Spectr. 2025 May 19:e0307424. [Abstract]
- Microbiol Spectr. 2022 Apr 25:e0251821. [Abstract]
- Microbiol Spectr. 2022 Feb 23;10(1):e0099121. [Abstract]
- Cardiovasc Toxicol. 2024 Sep;24(9):889-903. [Abstract]
- J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]
- Microb Pathog. 2024 Jun:191:106666. [Abstract]
- Appl Biochem Biotechnol. 2025 Aug 23. [Abstract]
- Eur J Clin Microbiol Infect Dis. 2025 Sep 29. [Abstract]
- Water. 2025 Jun 6.
- Infect Drug Resist. 2025 Oct 4:18:5239-5247. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- Anim Dis. 2021;1(1):26. [Abstract]
- J Microbiol Methods. 2026 Feb 25:107441. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- bioRxiv. 2026 Jan 19.
- Orebro University. 2024.
- bioRxiv. 2024 Nov 06.
- bioRxiv. 2024 May 10.
- Research Square Preprint. 2020 Jun.
- Patent. US20200101105A1.
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Others
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2D/3D Cell Culture and Differentiation
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Flow Cytometry
All Topoisomerase Isoforms
MoreAll Antibiotic Isoforms
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Biological Activity
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Quinolone |
Ciprofloxacin (Bay-09867) lactate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[1].
Ciprofloxacin (Bay-09867) lactate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Tendon cells
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Concentration:5, 10, 20 and 50 μg/mL
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Incubation Time:24 hours
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Result:Decreased the cellularity of tendon cells.
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Cell Line:Tendon cells
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Concentration:50 μg/mL
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Incubation Time:24 hours
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Result:Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.
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Cell Line:Tendon cells
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Concentration:50 μg/mL
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Incubation Time:0, 6, 12, 17 and 24 hours
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Result:Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulated the expression of PLK-1 protein.
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[3]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection; for 24 hours
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Result:Reduced the lung bacterial load in murine model of pneumonic plague.
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Animal Model:C57BL/6J mice[4]
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Dosage:100 mg/kg
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Administration:Oral gavage; daily, for 4 weeks
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Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
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Animal Model:C57BL/6J mice[4]
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Dosage:100 mg/kg
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Administration:Oral gavage; daily, for 4 weeks
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Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 97867-33-9
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Molecular Weight 421.42
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Formula C20H24FN3O6
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SMILES
O=C(C1=CN(C2CC2)C3=CC(N4CCNCC4)=C(C=C3C1=O)F)O.OC(C(O)=O)C
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Synonyms
Bay-09867 lactate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (46)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nature
2024 Aug;632(8027):1137-1144. PMID: 39085612 -
Nat Cell Biol
2024 Sep;26(9):1545-1557. PMID: 38997456 -
Adv Sci (Weinh)
A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics. [Abstract]2020 Jul 21;7(17):2001374. PMID: 32995131 -
Water Res
Variable cyanobacterial death modes caused by ciprofloxacin in the aquatic environment: Prioritizing antibiotic-photosynthetic protein interactions for risk assessment. [Abstract]2024 Nov 29:271:122885. PMID: 39642793
Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885. [Abstract]
Ciprofloxacin (CIP, 3 or 8 μg/L, 0-7 days) caused concentration-dependent damage in M. aeruginosa cells.
Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885. [Abstract]
Ciprofloxacin (CIP, 3 or 8 μg/L, 3 or 7 days) increased the release and decreased the biosynthesis of MC-LR in M. aeruginosa cells.
Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885. [Abstract]
Ciprofloxacin (CIP, 8 μg/L, 1 day) enriched gene ontology terms related to PSI in M. aeruginosa cells.
Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885. [Abstract]
Ciprofloxacin (CIP, 3 or 8 μg/L, 21 days) induced continuous cell lysis, with maximum lytic rates of ∼70% compared to the initial cell density.
Ciprofloxacin lactate purchased from MedChemExpress. Usage Cited in: Water Res. 2024 Nov 29:271:122885. [Abstract]
Ciprofloxacin (CIP, 3 or 8 μg/L, 1, 3, 5, or 7 days) induced cell death in M. aeruginosa.
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Water Res
Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]2023 Jul 15:240:120110. PMID: 37247434 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337 -
J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Genome Biol
Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota. [Abstract]2023 Apr 30;24(1):98. PMID: 37122023 -
NPJ Biofilms Microbiomes
Gut microbiota dysbiosis-mediated ceramides elevation contributes to corticosterone-induced depression by impairing mitochondrial function. [Abstract]2024 Oct 28;10(1):111. PMID: 39468065 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299 -
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J Med Chem
Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase. [Abstract]2025 Dec 11;68(23):25274-25289. PMID: 41277442 -
J Agric Food Chem
2025 Dec 23. PMID: 41436099 -
Anal Chim Acta
A natural fluorescent protein for ciprofloxacin sensing and mechanism study using molecular docking and circular dichroism. [Abstract]2022 Aug 15:1221:340082. PMID: 35934392 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Virulence
Bactericidal and anti-quorum sensing activity of repurposing drug Visomitin against Staphylococcus aureus. [Abstract]2024 Dec;15(1):2415952. PMID: 39390774 -
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PLoS Pathog
Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae. [Abstract]2024 Dec 31;20(12):e1012783. PMID: 39739989 -
Molecules
2023 Jun 8;28(12):4628. PMID: 37375183 -
Int J Antimicrob Agents
Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. [Abstract]2018 Aug;52(2):269-271. PMID: 29559273 -
Antimicrob Agents Chemother
Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae. [Abstract]2026 Apr;70(4):e0170625. PMID: 41810969 -
Antimicrob Agents Chemother
An enoyl-ACP reductase inhibitor, NITD-916, expresses anti- Mycobacterium abscessus activity. [Abstract]2025 May 23:e0024925. PMID: 40407337 -
Front Microbiol
Enrofloxacin Promotes Plasmid-Mediated Conjugation Transfer of Fluoroquinolone-Resistance Gene qnrS. [Abstract]2022 Feb 16:12:773664. PMID: 35250901 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
iScience
Analysis of microbiota reveals the underlying mechanism of PHF11 in the development of Enterococcus-regulated endometriotic cysts. [Abstract]2023 Oct 7;26(11):108158. PMID: 37915596 -
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 May 19:e0307424. PMID: 40387379 -
Microbiol Spectr
Phenotypic and Genotypic Characterization of Multidrug-Resistant Enterobacter hormaechei Carrying qnrS Gene Isolated from Chicken Feed in China. [Abstract]2022 Apr 25:e0251821. PMID: 35467399 -
Microbiol Spectr
The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis. [Abstract]2022 Feb 23;10(1):e0099121. PMID: 35019708 -
Cardiovasc Toxicol
Ciprofloxacin Accelerates Angiotensin-II-Induced Vascular Smooth Muscle Cells Senescence Through Modulating AMPK/ROS pathway in Aortic Aneurysm and Dissection. [Abstract]2024 Sep;24(9):889-903. PMID: 39138741 -
J Antimicrob Chemother
In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. [Abstract]2020 Jul 1;75(7):1850-1858. PMID: 32154866 -
Microb Pathog
Bacitracin-resistant Staphylococcus aureus induced in chicken gut and in vitro under bacitracin exposure. [Abstract]2024 Jun:191:106666. PMID: 38685360 -
Appl Biochem Biotechnol
Evaluation of Benzothiazole-Chalcone Hybrids: Apoptosis Induction, Docking Analysis, and Anticancer Potential in Gastric Cancer Cells. [Abstract]2025 Aug 23. PMID: 40848211 -
Eur J Clin Microbiol Infect Dis
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]2025 Sep 29. PMID: 41023358 -
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Infect Drug Resist
In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against Mycobacterium abscessus. [Abstract]2025 Oct 4:18:5239-5247. PMID: 41069760 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
Anim Dis
Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China. [Abstract]2021;1(1):26. PMID: 34778886 -
J Microbiol Methods
Comparison of agar-based and checkerboard methods to assess phage-antimicrobial synergy in Pseudomonas aeruginosa. [Abstract]2026 Feb 25:107441. PMID: 41759663 -
Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
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Purity & Documentation
References
[1]. Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58(6):1657-63. [Content Brief]
[2]. Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02434-16. [Content Brief]
[4]. LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153(9):e181804. [Content Brief]
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