1. Anti-infection
  2. Bacterial

Ciprofloxacin hydrochloride (Synonyms: Bay-09867 (hydrochloride))

Cat. No.: HY-B0356A Purity: 99.27%
Handling Instructions

Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

For research use only. We do not sell to patients.

Ciprofloxacin hydrochloride Chemical Structure

Ciprofloxacin hydrochloride Chemical Structure

CAS No. : 93107-08-5

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Free Sample (0.5-1 mg)   Apply now  
1 g USD 72 In-stock
Estimated Time of Arrival: December 31
5 g USD 108 In-stock
Estimated Time of Arrival: December 31
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Other Forms of Ciprofloxacin hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

IC50 & Target

Bacterial[1]

In Vitro

Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1]. Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2].

In Vivo

Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin hydrochloride (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. In a murine model of pneumonic plague, Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)). Intraperitoneal Ciprofloxacin hydrochloride reduces the lung bacterial load compare to controls treated with intraperitoneal PBS[3].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (33.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7189 mL 13.5943 mL 27.1887 mL
5 mM 0.5438 mL 2.7189 mL 5.4377 mL
10 mM 0.2719 mL 1.3594 mL 2.7189 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Bacterial inocula are prepared by suspending colonies into Mueller-Hinton broth (CAMHB) (containing Ciprofloxacin hydrochloride) from 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) on sheep blood agar (SBA) plates that are incubated at 35°C. Suspended cultures are diluted with CAMHB to a bacterial cell density of 105 CFU/mL adjusted based on the optical density at 600 nm. To each well of the 96-well plate, 50 μL of dilutions is added for a final inoculum of ~5×104 CFU/well. Plates are incubated at 35°C. MICs are determined visually at 18 to 24 h (B. anthracis) or 42 to 48 h (Y. pestis) and also by absorbance at 600 nm[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Female BALB/cAnNCrl (BALB/c) mice, 8 to 10 weeks old and 20 g (±4 g) are used in this assay. A single dose of Ciprofloxacin hydrochloride (30 mg/kg) is administered to mice (n=30) via the intraperitoneal (i.p.) route. The mice (n=3/time point/group) are culled at 1, 10, 20, or 30 min and 1, 1.5, 2, 4, 8, 12 h following Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) administration and 1, 15, or 30 min and 1, 2, 4, 6, 10, 18, or 24 h following DRCFI or CFI administration. Blood sampling points are chosen based upon the short half-life of Ciprofloxacin hydrochloride and longer half-life of CFI. Blood and lungs (whole organ) are collected post mortem for analysis. The lung doses following CFI or DRCFI administration are calculated using the concentration of Ciprofloxacin hydrochloride (Bay-09867 (hydrochloride)) in the lung samples at 1 min post-administration[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

367.80

Formula

C₁₇H₁₉ClFN₃O₃

CAS No.

93107-08-5

SMILES

[H]Cl.O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O

Storage

4°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Ciprofloxacin hydrochloride
Cat. No.:
HY-B0356A
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Ciprofloxacin hydrochloride

Cat. No.: HY-B0356A