1. Cell Cycle/DNA Damage
    Apoptosis
    Anti-infection
    Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. Topoisomerase
    Apoptosis
    Antibiotic
    Bacterial
    Mitochondrial Metabolism
    Reactive Oxygen Species
  3. Ciprofloxacin monohydrochloride

Ciprofloxacin monohydrochloride (Synonyms: Bay-09867 monohydrochloride)

Cat. No.: HY-B0356A Purity: 99.78%
Handling Instructions

Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity.

For research use only. We do not sell to patients.

Ciprofloxacin monohydrochloride Chemical Structure

Ciprofloxacin monohydrochloride Chemical Structure

CAS No. : 93107-08-5

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Based on 14 publication(s) in Google Scholar

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Description

Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].

In Vitro

Ciprofloxacin (Bay-09867) monohydrochloride (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[1].
Ciprofloxacin (Bay-09867) monohydrochloride shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Tendon cells
Concentration: 5, 10, 20 and 50 μg/mL
Incubation Time: 24 hours
Result: Decreased the cellularity of tendon cells.

Cell Cycle Analysis[1]

Cell Line: Tendon cells
Concentration: 50 μg/mL
Incubation Time: 24 hours
Result: Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.

Western Blot Analysis[1]

Cell Line: Tendon cells
Concentration: 50 μg/mL
Incubation Time: 0, 6, 12, 17 and 24 hours
Result: Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulated the expression of PLK-1 protein.
In Vivo

Ciprofloxacin (Bay-09867) monohydrochloride (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague[3].
Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4].
Ciprofloxacin (Bay-09867) monohydrochloride (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice[3]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; for 24 hours
Result: Reduced the lung bacterial load in murine model of pneumonic plague.
Animal Model: C57BL/6J mice[4]
Dosage: 100 mg/kg
Administration: Oral gavage; daily, for 4 weeks
Result: Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
Animal Model: C57BL/6J mice[4]
Dosage: 100 mg/kg
Administration: Oral gavage; daily, for 4 weeks
Result: Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
Clinical Trial
Molecular Weight

367.80

Formula

C17H19ClFN3O3

CAS No.
SMILES

[H]Cl.O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCNCC4)=C3)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (33.99 mM; Need ultrasonic)

DMSO : 5 mg/mL (13.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7189 mL 13.5943 mL 27.1887 mL
5 mM 0.5438 mL 2.7189 mL 5.4377 mL
10 mM 0.2719 mL 1.3594 mL 2.7189 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.36 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.78%

References
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Product Name:
Ciprofloxacin monohydrochloride
Cat. No.:
HY-B0356A
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