1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topo I Inhibitors

Topo I Inhibitors

Topoisomerase

Topo I

Topo II

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform Topo I together.

Please try each isoform separately.

Topo I Specific Inhibitors & Agonists
Product Name Topo I Topo II Topo I Selectivity Purity
Irinotecan
Topoisomerase I
  Selective Inhibitor ≥95.0%
SN-38
Topoisomerase I
  Selective Inhibitor 99.80%
Camptothecin
Topoisomerase I, IC50: 679 nM
  Selective Inhibitor ≥98.0%
Exatecan mesylate
Topoisomerase I, IC50: 0.975 μg/mL
  Selective Inhibitor ≥98.0%
Topotecan Hydrochloride
Topoisomerase I
  Selective Inhibitor 99.74%
Dxd
Topoisomerase I, IC50: 0.31 μM
  Selective Inhibitor
Irinotecan hydrochloride
Topoisomerase I
  Selective Inhibitor 99.75%
Betulinic acid
Topoisomerase I, IC50: 5 μM
  Selective Inhibitor ≥98.0%
β-Lapachone
Topoisomerase I
  Selective Inhibitor 99.85%
Irinotecan hydrochloride trihydrate
Topoisomerase I
  Selective Inhibitor 99.87%
PNU-159682
Topoisomerase I
  Selective Inhibitor 97.24%
Genz-644282
Topoisomerase I
  Selective Inhibitor 98.92%
(S)-10-Hydroxycamptothecin
Topoisomerase I
  Selective Inhibitor 99.38%
LMP744 hydrochloride
Top1
  Selective Inhibitor 99.21%
Coralyne chloride
Topoisomerase I
  Selective Inhibitor 99.34%
9-amino-CPT
Topoisomerase I
  Selective Inhibitor 99.05%
Gimatecan
Topoisomerase I
  Selective Inhibitor ≥98.0%
Karenitecin
Topoisomerase I
  Selective Inhibitor 98.30%
Namitecan
Topoisomerase I
  Selective Inhibitor 98.11%
Topotecan
Topoisomerase I
  Selective Inhibitor
CH-0793076
Topoisomerase I, IC50: 2.3 μM
  Selective Inhibitor
Edotecarin
Topoisomerase I, IC50: 50 nM
  Selective Inhibitor 98.39%
(±)-10-Hydroxycamptothecin
Topoisomerase I
  Selective Inhibitor 99.44%
CH-0793076 TFA
Topoisomerase I, IC50: 2.3 μM
  Selective Inhibitor 98.92%
SW044248
Topoisomerase I
  Selective Inhibitor 99.60%
LMP744
Top1
  Selective Inhibitor
Exatecan
Topoisomerase I, IC50: 2.2 μM
  Selective Inhibitor
Datopotamab deruxtecan
Topoisomerase I
  Selective Inhibitor
T-2513 hydrochloride
Topoisomerase I
  Selective Inhibitor
T-2513
Topoisomerase I
  Selective Inhibitor
Podocarpusflavone A
Topoisomerase I, IC50: 119.425 μM
  Selective Inhibitor
(±)-Evodiamine
Top1
  Selective Inhibitor
TP3011
Topoisomerase I
  Selective Inhibitor
Doxorubicin hydrochloride
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
Pan Inhibitor ≥99.0%
Hycanthone
Topoisomerase I
Topoisomerase II
Pan Inhibitor 99.73%
Belotecan hydrochloride
Top1
  Pan Inhibitor 98.82%
Proscillaridin A
Topoisomerase I, IC50: 30 nM
Topoisomerase II, IC50: 100 nM
Pan Inhibitor 99.74%
TAS-103 dihydrochloride
Topoisomerase I
Topoisomerase II
Pan Inhibitor 99.70%
Doxorubicin
Topoisomerase I, IC50: 0.8 μM
Topoisomerase II, IC50: 2.67 μM
Pan Inhibitor
Zabofloxacin
Topoisomerase I
Topoisomerase II
Pan Inhibitor
Zabofloxacin hydrochloride
Topoisomerase I
Topoisomerase II
Pan Inhibitor 98.06%
TAS-103
Topoisomerase I
Topoisomerase II
Pan Inhibitor
Intoplicine
Topoisomerase I
Topoisomerase II
Pan Inhibitor 98.36%
Huanglongmycin N
Topoisomerase I, EC50: 14 μM
  Pan Inhibitor
Dxd-d5
Topoisomerase I, IC50: 0.31 μM
  Inhibitor
Groenlandicine
Topoisomerase I
  Agonist 99.69%
Rebeccamycin
Topoisomerase I
  Inhibitor
Intoplicine dimesylate
Topoisomerase I
Topoisomerase II
Inhibitor