1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Proscillaridin A

Proscillaridin A 

Cat. No.: HY-N2331 Purity: 99.74%
Handling Instructions

Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively.

For research use only. We do not sell to patients.

Proscillaridin A Chemical Structure

Proscillaridin A Chemical Structure

CAS No. : 466-06-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 263 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 263 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 225 In-stock
Estimated Time of Arrival: December 31
10 mg USD 375 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1].

IC50 & Target[1]

Topoisomerase I

30 nM (IC50)

Topoisomerase II

100 nM (IC50)

In Vitro

Proscillaridin A (0-160 nM; 48 hours) reveals the antiproliferative response in a time- as well as dose-dependent manner in MCF-7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

530.65

Formula

C30H42O8

CAS No.
SMILES
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8845 mL 9.4224 mL 18.8448 mL
5 mM 0.3769 mL 1.8845 mL 3.7690 mL
10 mM 0.1884 mL 0.9422 mL 1.8845 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.74%

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Product Name:
Proscillaridin A
Cat. No.:
HY-N2331
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