466-06-8
466-06-8
Chemical Structure
Proscillaridin A
- CAS No.: 466-06-8
- Formula:C30H42O8
- Molecular Weight:530.65
IUPAC Name: 5-((3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
InChIKey: MYEJFUXQJGHEQK-ALRJYLEOSA-N
SMILES: O[C@@]([C@@]1(CC2)C)(CC[C@@H]1C(C=C3)=COC3=O)[C@@](CCC4=C[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)CC6)([H])[C@@]2([H])[C@]46C
Biological Activity: Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Proscillaridin A | 99.0% | Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively. | ||||||||||||||||||||
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Proscillaridin A (Standard) | ≥98% | Proscillaridin A (Standard) is the analytical standard of Proscillaridin A. This product is intended for research and analytical applications. Proscillaridin A is a potent poison of topoisomerase I/II activity with IC50 values of 30 nM and 100 nM, respectively. | ||||||||||||||||||||
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Meproscillarin | Meproscillarin (Methylproscillaridin) is a glycoside. Meproscillarin can be used for research of heart failure. | |||||||||||||||||||||
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Hellebrin | Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways. | |||||||||||||||||||||
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Telocinobufagin | 99.50% | Telocinobufagin (Telobufotoxin; Telocinobufogenin) is an orally active bufadienolide with potential anti-tumor effects. Telocinobufagin exerts its anti-cancer effects on non-small cell carcinoma, osteosarcoma, thyroid cancer, breast cancer and head and neck squamous cell carcinoma by inhibiting the STAT3, JAK2/STAT3, LARP1-mTOR, PI3K/Akt/Snail and PLK1 pathways, and can also induce tumor cell apoptosis. Telocinobufagin enhances the Th1 immune response and protects against Salmonella typhimurium infection. Telocinobufagin has a strong cardiac-stimulating effect by inhibiting the activity of Na+/K+-ATPase, and it can promote renal fibrosis. Telocinobufagin demonstrates non-opioid analgesic effects in various acute pain models. | ||||||||||||||||||||
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Scillaren A | Scillaren A is a cardiac glycoside, can be isolated from the bulbs of D. coromandeliana. | |||||||||||||||||||||
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3-epi-Bufalin | 99.01% | 3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide. | ||||||||||||||||||||
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Bersaldegenin 3-acetate | ||||||||||||||||||||||
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5α-4,5-Dihydroscillaren A | 5α-4,5-Dihydroscillaren A is a bufadienolide that can be found in the bulbs of Urginea sanguinea. | |||||||||||||||||||||
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Deglucohellebrin | Deglucohellebrin is a natural product. | |||||||||||||||||||||
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14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide | 14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide (compound 10) is a butadiene lactone that can be used in related research in the field of life sciences. | |||||||||||||||||||||
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Scillarenin | Scillarenin is a plant bufadienolide and cardiotonic agent. Scillarenin selectively inhibits replication of picornaviruses, in particular, rhinovirus. | |||||||||||||||||||||
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