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Betulinic acid

(Synonyms: Lupatic acid; Betulic acid)
35 Cited Publications
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Based on 35 publication(s) in Google Scholar

Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties. Betulinic acid can cross the blood-brain barrier.

For research use only. We do not sell to patients.

  • Purity: 99.88%
  • CAS No.: 472-15-1
  • Formula: C30H48O3
  • Molecular Weight:456.70
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Betulinic acid Chemical Structure
    Betulinic acid Chemical Structure
  • Experimental Validation Results for Betulinic acid
  • Experimental Validation Results for Betulinic acid
  • Experimental Validation Results for Betulinic acid
  • Experimental Validation Results for Betulinic acid
  • Experimental Validation Results for Betulinic acid
  • Experimental Validation Results for Betulinic acid
CAS No.: 472-15-1
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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WBHistological Imaging/StainingBio/Physico-chemical AssayIn Vivo Efficacy StudyIF
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  • Betulinic acid Chemical Structure
    Betulinic acid Chemical Structure
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    Betulinic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Nov 13;23(1):1282. [Abstract]

    Customer Validation
     Serum levels of ALT and AST were measured to assess liver function in Betulinic acid (BA) (20, 50 mg/kg, i.g.) treatment group significantly reduced, providing a biochemical evaluation of hepatic injury.

  • 1/16

    Betulinic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Nov 13;23(1):1282. [Abstract]

    Customer Validation
     Representative images illustrating the morphological alterations in the liver of mice from different treatment groups, highlighting the effects of Betulinic acid (BA) (20, 50 mg/kg, i.g.) on hepatic appearance.

  • 1/16

    Betulinic acid purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 May 1;12(8):3656-3675. [Abstract]

    Customer Validation
     Betulinic acid (20 μM) significantly reversed the down-regulation of nNOS and CAPON expression induced by fluoxetine.

  • 1/16

    Betulinic acid purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2021 Mar 11;17(4):1138-1152. [Abstract]

    Customer Validation
     Longitudinal spinal cord sections from the indicated groups at day 14 were analyzed by HE staining and Masson staining.

  • 1/16

    Betulinic acid purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2021 Mar 11;17(4):1138-1152. [Abstract]

    Customer Validation
     With Betulinic acid (BA) (20 mg/kg, i.p.) treatment, animals had higher neuronal MAP2 expression, and more SYN-positive synapses onto ventral motor neurons compared with the untreated SCI group.

  • 1/16

    Betulinic acid purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Sep 13;10:1017. [Abstract]

    Customer Validation
     Immunofluorescence is performed to determine the LC3II expression level to show the autophagosomes in the cells of the skin flaps: autophagosomes (green) in the dermis in area II; nuclei counterstained with DAPI (blue).

  • Betulinic acid