Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives

  • Bioorg Med Chem Lett. 1998 May 19;8(10):1267-72. doi: 10.1016/s0960-894x(98)00202-9.
I C Sun  1 ,  J K Shen ,  H K Wang ,  L M Cosentino ,  K H Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill 27599-7360, USA.
PMID: 9871747 DOI: 10.1016/s0960-894x(98)00202-9
Abstract

Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 microM and 21,515, respectively.