Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants

  • J Nat Prod. 2008 Jan;71(1):102-5. doi: 10.1021/np070560c.
José C Aponte  1 ,  Abraham J Vaisberg ,  Rosario Rojas ,  Luz Caviedes ,  Walter H Lewis ,  Gerardo Lamas ,  César Sarasara ,  Robert H Gilman ,  Gerald B Hammond
Affiliations
  • 1. Department of Chemistry, University of Louisville, KY 40292, USA.
PMID: 18163590 DOI: 10.1021/np070560c
Abstract

The antiproliferative bioassay-guided fractionation of five Peruvian Plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2',4'-dihydroxy-6'-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium Tuberculosis is also reported.