Tuberculosis

Tuberculosis is a contagious bacterial infection caused by Mycobacterium tuberculosis, primarily affecting the lungs but capable of involving other organs. It often presents as latent infection without symptoms, but can progress to active disease characterized by persistent cough, weight loss, fever, and night sweats. Transmitted via airborne droplets, untreated tuberculosis can be fatal. Effective treatment requires prolonged antibiotic therapy.

References:

[1]. Tuberculosis. sciencedirect.

Tuberculosis (6):

Targets:	Bacterial (4) MHC (1) Arginase (1) Apoptosis (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-112885A

nor-NOHA acetate	1140844-63-8	99.52%
nor-NOHA acetate is a selective and reversible Arginase inhibitor. nor-NOHA acetate induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism.

HY-P6312

ESAT6 Epitope	183273-40-7
ESAT6 Epitope is a ESAT6 CD4⁺ T cell epitope. ESAT6 Epitope binds to MHC class I molecules with an IC₅₀ value of approximately 180 nM. ESAT6 Epitope has weak immunogenicity. ESAT6 Epitope can be used in studies related to pulmonary tuberculosis.

HY-179444

Antituberculosis agent-17
Antituberculosis agent-17 (compound 21) is a potent and selective antituberculosis agent. Antituberculosis agent-17 displays excellent anti-Tuberculosis (TB) activity against H37Rv, MDR and XDR strains of TB (MIC = 0.2-0.78 μM). Antituberculosis agent-17 exhibits selectivity for Mycobacterium tuberculosis over selected non-TB forming mycobacteria and bacteria. Antituberculosis agent-17 can be used for TB research.

HY-181008

Antitubercular agent-56
Antitubercular agent-56, a Questiomycin A (HY-N8439) derivative, is a potent and orally active antitubercular agent. Antitubercular agent-56 disrupts mycobacterial envelope integrity by inhibiting FabD (K_d = 9.39 μM; IC₅₀ = 49.60 μM). Antitubercular agent-56 exhibits good intracellular antimycobacterial activity against Mycobacterium tuberculosis (MTB) and drug-resistant MTB both in vitro and in vivo. Antitubercular agent-56 can be used for research on tuberculosis (TB).

HY-W791994A

BVL3572S	1258544-63-6
BVL3572S, a hydroxamic acid derivative, exhibits potent bactericidal activity against Mycobacterium tuberculosis (Mtb) with a MIC₉₀ of 1.7 µM. BVL3572S inhibits pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA to kill Mtb. BVL3572S can be used for tuberculosis (TB) research.

HY-179532

Antimycobacterial agent-14
Antimycobacterial agent-14 (compound 20s) is an antimycobacterial agent with potent activity against Mycobacterium tuberculosis (M.tb) H37Ra strain with a MIC of 11.37 μM. Antimycobacterial agent-14 can be used for tuberculosis (TB) research.

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