nor-NOHA dihydrochloride (Synonyms: Nω-Hydroxy-nor-L-arginine dihydrochloride)

Cat. No.: HY-112885C Purity: 98.85%: FAQs
Data Sheet SDS COA Handling Instructions

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nor-NOHA dihydrochloride is a selective and reversible arginase inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism.

For research use only. We do not sell to patients.

nor-NOHA dihydrochloride Chemical Structure

CAS No. : 291758-32-2

Size	Price	Stock	Quantity
5 mg	USD 155	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of nor-NOHA dihydrochloride:

nor-NOHA monoacetate In-stock
nor-NOHA acetate Get quote

1 Publications Citing Use of MCE nor-NOHA dihydrochloride

•Front Cell Dev Biol. 2021 Dec 23;9:741911. [Abstract]

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Description

Molecular Weight

249.10

Formula

C₅H₁₄Cl₂N₄O₃

CAS No.

291758-32-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

OC([C@@H](N)CCNC(NO)=N)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (401.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0145 mL	20.0723 mL	40.1445 mL
5 mM	0.8029 mL	4.0145 mL	8.0289 mL
10 mM	0.4014 mL	2.0072 mL	4.0145 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.85%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB) HNMR (506 KB) LCMS (85 KB)

Handling Instructions (2659 KB)

References

[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0145 mL	20.0723 mL	40.1445 mL	100.3613 mL
	5 mM	0.8029 mL	4.0145 mL	8.0289 mL	20.0723 mL
	10 mM	0.4014 mL	2.0072 mL	4.0145 mL	10.0361 mL
	15 mM	0.2676 mL	1.3382 mL	2.6763 mL	6.6908 mL
	20 mM	0.2007 mL	1.0036 mL	2.0072 mL	5.0181 mL
	25 mM	0.1606 mL	0.8029 mL	1.6058 mL	4.0145 mL
	30 mM	0.1338 mL	0.6691 mL	1.3382 mL	3.3454 mL
	40 mM	0.1004 mL	0.5018 mL	1.0036 mL	2.5090 mL
	50 mM	0.0803 mL	0.4014 mL	0.8029 mL	2.0072 mL
	60 mM	0.0669 mL	0.3345 mL	0.6691 mL	1.6727 mL
	80 mM	0.0502 mL	0.2509 mL	0.5018 mL	1.2545 mL
	100 mM	0.0401 mL	0.2007 mL	0.4014 mL	1.0036 mL

nor-NOHA dihydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nor-NOHA291758-32-2Nω-Hydroxy-nor-L-arginineApoptosisArginaseArginase InhibitorARG2Anti-leukemicImunosuppressionEdothelial dysfunctionInhibitorinhibitorinhibit

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nor-NOHA dihydrochloride (Synonyms: Nω-Hydroxy-nor-L-arginine dihydrochloride)

Customer Review

Other Forms of nor-NOHA dihydrochloride:

nor-NOHA dihydrochloride Related Antibodies

1 Publications Citing Use of MCE nor-NOHA dihydrochloride

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Biological Activity

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References

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Complete Stock Solution Preparation Table

nor-NOHA dihydrochloride Related Classifications

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