2. Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis
  3. Arginase Apoptosis
  4. nor-NOHA acetate

nor-NOHA acetate  (Synonyms: Nω-Hydroxy-nor-L-arginine acetate)

Cat. No.: HY-112885A Purity: 99.52%
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nor-NOHA acetate is a selective and reversible Arginase inhibitor. nor-NOHA acetate induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism.

For research use only. We do not sell to patients.

CAS No. : 1140844-63-8

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Based on 5 publication(s) in Google Scholar

Other Forms of nor-NOHA acetate:

nor-NOHA acetate Related Antibodies

Top Publications Citing Use of Products

    nor-NOHA acetate purchased from MedChemExpress. Usage Cited in: Cell. 2025 Dec 11;188(25):7291-7308.e23.  [Abstract]

    Bar plots showing proportions of TNF-α+ T cells in fetal liver whole blood following PMA simulation. T cells were cultured alone (light green) or co-cultured with matched fetal neutrophils (orange) in the presence or absence of ARG1 inhibitor (nonor-NOHA monoacetate; overnight) or L-arginine supplementation, as indicated on the x axis.

    nor-NOHA acetate purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 Sep 30;39(18):e71057.  [Abstract]

    nonor-NOHA monoacetate (1, 10, 50, 100 μM) increased HaCaT cell viability.

    nor-NOHA acetate purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 Sep 30;39(18):e71057.  [Abstract]

    nonor-NOHA monoacetate (100 μM) increased K5 expression in HaCaT cells.

    nor-NOHA acetate purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Dec 23;9:741911.  [Abstract]

    nor-NOHA monoacetate (nor-NOHA) efficiently reduced immunosuppressive activity. Arg1 inhibitor (nor-NOHA) and/or iNOS inhibitor [L-NG-Monomethylarginine, Acetate Salt (L-NMMA)] were added in PMN-MDSCs’ suppressive function assays.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    nor-NOHA acetate is a selective and reversible Arginase inhibitor. nor-NOHA acetate induces Apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism[1][2][3][4].

    IC50 & Target

    Arginase[1]
    In Vitro

    nor-NOHA (0.1-1 mM, 72 h) acetate induces apoptosis in a dose-dependent manner under hypoxia (1.5% O2) in K562 cells[1].
    nor-NOHA (1 mM, 72 h) acetate attenuates hypoxia-mediated resistance towards Imatinib (HY-15463) in K562 or KCL22 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    nor-NOHA acetate Related Antibodies
    In Vivo

    Nor-NOHA (0.04 mg/g of mouse; i.p.; daily) acetate modulates arginase to alter immune responses in experimental mouse models of pulmonary tuberculosis, including in the setting of HIV co-infection[4].
    nor-NOHA (100 mg/kg, i.v., once time) acetate induces a significant reduction of infarct size in male Sprague-Dawley rats[2].
    nor-NOHA (100 mg/kg, i.v., once time) acetate increases plasma citrulline and nitrite levels and decreases the ornithine plasma levels in male Sprague-Dawley rats[2].
    nor-NOHA (100 mg/kg; intravenous penile vein injection) acetate improves liver I/R injury[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Sprague-Dawley rats subjected to ischemia-reperfusion[2]
    Dosage: 100 mg/kg
    Administration: Intravenous injection (i.v.)
    Result: Induced a significant reduction of infarct size to 39%.
    Did not reduce infarct size when administered together with cPTIO or L-NMMA.
    Molecular Weight

    296.28

    Formula

    C9H20N4O7
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (337.52 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3752 mL 16.8759 mL 33.7519 mL
    5 mM 0.6750 mL 3.3752 mL 6.7504 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.52%

    SDS (252 KB)

    COA (250 KB) RP-HPLC (161 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.3752 mL 16.8759 mL 33.7519 mL 84.3796 mL
    5 mM 0.6750 mL 3.3752 mL 6.7504 mL 16.8759 mL
    10 mM 0.3375 mL 1.6876 mL 3.3752 mL 8.4380 mL
    15 mM 0.2250 mL 1.1251 mL 2.2501 mL 5.6253 mL
    20 mM 0.1688 mL 0.8438 mL 1.6876 mL 4.2190 mL
    25 mM 0.1350 mL 0.6750 mL 1.3501 mL 3.3752 mL
    30 mM 0.1125 mL 0.5625 mL 1.1251 mL 2.8127 mL
    40 mM 0.0844 mL 0.4219 mL 0.8438 mL 2.1095 mL
    50 mM 0.0675 mL 0.3375 mL 0.6750 mL 1.6876 mL
    60 mM 0.0563 mL 0.2813 mL 0.5625 mL 1.4063 mL
    80 mM 0.0422 mL 0.2109 mL 0.4219 mL 1.0547 mL
    100 mM 0.0338 mL 0.1688 mL 0.3375 mL 0.8438 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    nor-NOHA acetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    nor-NOHA1140844-63-8Nω-Hydroxy-nor-L-arginineArginaseApoptosispulmonary tuberculosisI/R injuryAnti-leukemicImunosuppressionEdothelial dysfunctionInhibitorinhibitorinhibit

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