nor-NOHA acetate (Synonyms: Nω-Hydroxy-nor-L-arginine acetate)

Cat. No.: HY-112885A: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism.

For research use only. We do not sell to patients.

nor-NOHA acetate Chemical Structure

CAS No. : 1140844-63-8

Size	Price	Stock
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 244	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in Water	USD 244	Ask For Quote & Lead Time
Solid
1 mg	USD 75	Ask For Quote & Lead Time
5 mg	USD 235	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of nor-NOHA acetate:

nor-NOHA monoacetate nor-NOHA dihydrochloride

Other Forms of nor-NOHA acetate:

nor-NOHA monoacetate In-stock
nor-NOHA dihydrochloride In-stock

1 Publications Citing Use of MCE nor-NOHA acetate

•Front Cell Dev Biol. 2021 Dec 23;9:741911. [Abstract]

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Arginase^[1]

Molecular Weight

296.28

Formula

C₉H₂₀N₄O₇

CAS No.

1140844-63-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 200 mg/mL (675.04 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3752 mL	16.8759 mL	33.7519 mL
5 mM	0.6750 mL	3.3752 mL	6.7504 mL
10 mM	0.3375 mL	1.6876 mL	3.3752 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.3752 mL	16.8759 mL	33.7519 mL	84.3796 mL
	5 mM	0.6750 mL	3.3752 mL	6.7504 mL	16.8759 mL
	10 mM	0.3375 mL	1.6876 mL	3.3752 mL	8.4380 mL
	15 mM	0.2250 mL	1.1251 mL	2.2501 mL	5.6253 mL
	20 mM	0.1688 mL	0.8438 mL	1.6876 mL	4.2190 mL
	25 mM	0.1350 mL	0.6750 mL	1.3501 mL	3.3752 mL
	30 mM	0.1125 mL	0.5625 mL	1.1251 mL	2.8127 mL
	40 mM	0.0844 mL	0.4219 mL	0.8438 mL	2.1095 mL
	50 mM	0.0675 mL	0.3375 mL	0.6750 mL	1.6876 mL
	60 mM	0.0563 mL	0.2813 mL	0.5625 mL	1.4063 mL
	80 mM	0.0422 mL	0.2109 mL	0.4219 mL	1.0547 mL
	100 mM	0.0338 mL	0.1688 mL	0.3375 mL	0.8438 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

nor-NOHA acetate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nor-NOHA1140844-63-8Nω-Hydroxy-nor-L-arginineArginaseApoptosisInhibitorinhibitorinhibit

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