Immunosuppression

Immunosuppression refers to the deliberate reduction of immune system activity to prevent organ transplant rejection, manage autoimmune diseases, or achieve immunologic tolerance. It is commonly induced through pharmacological agents such as cyclosporine, azathioprine, corticosteroids, FK506, and rapamycin, which inhibit lymphocyte proliferation and activation, or via monoclonal antibodies, irradiation in transplant recipients, or natural immune deficiency states like HIV/AIDS where CD4+ T cells are depleted. Combination therapies are employed to balance efficacy against acute rejection with minimized toxicity, while specific immunosuppression can lead to antigen-induced tolerance. This strategy is essential in solid organ and bone marrow transplantation, as well as in treating various immune-mediated disorders.

References:

[1]. Immunosuppression. sciencedirect.

Immunosuppression (1):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-P11699

AAPDNRETF	179953-98-1
AAPDNRETF is a dominant minor histocompatibility antigen presented by H-2D^b， which antigen is expressed in C57BL/6 mice and can be recognized by T cells from C3H.SW mice, thereby inducing a strong immune response. AAPDNRETF can induce graft-versus-host disease in irradiated C57BL/6 recipient mice via transfer of sensitized T lymphocytes. AAPDNRETF is applicable to the research of graft-versus-host disease.

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