2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Arginase
  4. nor-NOHA

nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism.

It is advisable to consider the salt form (nor-NOHA dihydrochloride) that retains the same biological activity.

For research use only. We do not sell to patients.

CAS No. : 189302-40-7

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nor-NOHA Related Antibodies

Top Publications Citing Use of Products

    nor-NOHA purchased from MedChemExpress. Usage Cited in: Cell. 2025 Dec 11;188(25):7291-7308.e23.  [Abstract]

    Bar plots showing proportions of TNF-α+ T cells in fetal liver whole blood following PMA simulation. T cells were cultured alone (light green) or co-cultured with matched fetal neutrophils (orange) in the presence or absence of ARG1 inhibitor (nonor-NOHA monoacetate; overnight) or L-arginine supplementation, as indicated on the x axis.

    nor-NOHA purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 Sep 30;39(18):e71057.  [Abstract]

    nonor-NOHA monoacetate (1, 10, 50, 100 μM) increased HaCaT cell viability.

    nor-NOHA purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 Sep 30;39(18):e71057.  [Abstract]

    nonor-NOHA monoacetate (100 μM) increased K5 expression in HaCaT cells.

    nor-NOHA purchased from MedChemExpress. Usage Cited in: Front Cell Dev Biol. 2021 Dec 23;9:741911.  [Abstract]

    nor-NOHA monoacetate (nor-NOHA) efficiently reduced immunosuppressive activity. Arg1 inhibitor (nor-NOHA) and/or iNOS inhibitor [L-NG-Monomethylarginine, Acetate Salt (L-NMMA)] were added in PMN-MDSCs’ suppressive function assays.

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    Description

    nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism[1][2].

    In Vitro

    nor-NOHA (0.1-1 mM, 72 h) induces apoptosis in a dose-dependent manner under hypoxia (1.5% O2) in K562 cells[1]. nor-NOHA (1 mM, 72 h) attenuates hypoxia-mediated resistance towards imatinib in K562 or KCL22 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    nor-NOHA Related Antibodies
    In Vivo

    nor-NOHA (100 mg/kg, i.v., once time) induces a significant reduction of infarct size in male Sprague-Dawley rats[2]. nor-NOHA (100 mg/kg, i.v., once time) increases plasma citrulline and nitrite levels and decreases the ornithine plasma levels in male Sprague-Dawley rats[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    176.17

    Formula

    C5H12N4O3
    CAS No.
    SMILES

    O=C(O)[C@@H](N)CCNC(NO)=N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    H2O : 250 mg/mL (1419.08 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.6763 mL 28.3817 mL 56.7634 mL
    5 mM 1.1353 mL 5.6763 mL 11.3527 mL
    View the Complete Stock Solution Preparation Table

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Purity & Documentation
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    Complete Stock Solution Preparation Table

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.6763 mL 28.3817 mL 56.7634 mL 141.9084 mL
    5 mM 1.1353 mL 5.6763 mL 11.3527 mL 28.3817 mL
    10 mM 0.5676 mL 2.8382 mL 5.6763 mL 14.1908 mL
    15 mM 0.3784 mL 1.8921 mL 3.7842 mL 9.4606 mL
    20 mM 0.2838 mL 1.4191 mL 2.8382 mL 7.0954 mL
    25 mM 0.2271 mL 1.1353 mL 2.2705 mL 5.6763 mL
    30 mM 0.1892 mL 0.9461 mL 1.8921 mL 4.7303 mL
    40 mM 0.1419 mL 0.7095 mL 1.4191 mL 3.5477 mL
    50 mM 0.1135 mL 0.5676 mL 1.1353 mL 2.8382 mL
    60 mM 0.0946 mL 0.4730 mL 0.9461 mL 2.3651 mL
    80 mM 0.0710 mL 0.3548 mL 0.7095 mL 1.7739 mL
    100 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4191 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    nor-NOHA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    nor-NOHA189302-40-7Nω-Hydroxy-nor-L-arginineApoptosisArginaseSprague-DawleyK562,KCL22apoptosisanti-leukemic activityendothelial dysfunctionimmunosuppression and metabolismInhibitorinhibitorinhibit

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