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Results for "

Sprague-Dawley

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (1) Akt (1) Amino Acid Derivatives (1) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (2) Autophagy (3) Bacterial (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) COX (1) Cytochrome P450 (2) Dopamine Receptor (2) Endogenous Metabolite (3) Estrogen Receptor/ERR (1) GlyT (1) HIV (1) iGluR (1) mTOR (1) Neuropeptide Y Receptor (2) NF-κB (1) Opioid Receptor (1) PD-1/PD-L1 (1) PKG (1) PPAR (1) Prostaglandin Receptor (2) PROTACs (2) Reverse Transcriptase (1) Sodium Channel (2) Src (1) STAT (1) TAM Receptor (2) TGF-beta/Smad (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (11) Endocrinology (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (13)

By Targets:

5-HT Receptor (1)

Adenosine Receptor (1)

Akt (1)

Amino Acid Derivatives (1)

Aminopeptidase (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (2)

Autophagy (3)

Bacterial (1)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Caspase (1)

COX (1)

Cytochrome P450 (2)

Dopamine Receptor (2)

Endogenous Metabolite (3)

Estrogen Receptor/ERR (1)

GlyT (1)

HIV (1)

iGluR (1)

mTOR (1)

Neuropeptide Y Receptor (2)

NF-κB (1)

Opioid Receptor (1)

PD-1/PD-L1 (1)

PKG (1)

PPAR (1)

Prostaglandin Receptor (2)

PROTACs (2)

Reverse Transcriptase (1)

Sodium Channel (2)

Src (1)

STAT (1)

TAM Receptor (2)

TGF-beta/Smad (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (11)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (4)

Neurological Disease (13)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N11925

(+)-Osbeckic acid	Others	Cardiovascular Disease
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM .

HY-162345

CK-963	Others	Cardiovascular Disease
CK-963 is an activator for cardiac troponin (cTnC) with K_i of 11.5 μM. CK-963 exhibits activity in enhancing cardiac contractility in Sprague-Dawley rats .

HY-151360

NHE3-IN-3	Sodium Channel	Metabolic Disease
NHE3-IN-3 (Compound 1) is a Na ⁺/H ⁺ exchanger isoform 3 (NHE3) inhibitor with pIC₅₀ of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats .

HY-N2196

Ajugasterone C
Ajugasterone C is an ecdysteroid isolated from Leuzea carthamoides. Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to Carrageenan-induced inflammation in Sprague Dawley rats .

HY-114761

Prostaglandin F2α dimethyl amine	Prostaglandin Receptor	Cardiovascular Disease
Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP) . Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590) .

HY-121123

Adamantanine 2-Aminoadamantane-2-carboxylic acid	Aminopeptidase	Cancer
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5 .

HY-146429

NaPi2b-IN-3	Others	Metabolic Disease
NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC₅₀s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia .

HY-W250580

Dimethicone	Biochemical Assay Reagents	Others
Dimethicone is an orally active biochemical assay reagents consisting of a fully methylated linear siloxane polymer whose ends are blocked by trimethylsiloxane units. Dimethicone can lubricate hair and physically block the respiratory system of lice to remove lice. Dimethicone has potential applications in cosmetics and daily cleaning products .

HY-162399

PD-L1-IN-6	PD-1/PD-L1 STAT	Inflammation/Immunology
PD-L1-IN-6 (Compound 16) is an orally active inhibitor for PD-L1 expression in neutrophil by targeting STAT3 with K_D of 90.5 nmol/L. PD-L1-IN-6 promotes neutrophil-mediated antifungal immunoresponse .

HY-163443

PPAR agonist 4	PPAR	Others
PPAR agonist 4 (Compound 12) is an orally active agonist for peroxisome proliferator-activated receptor (PPAR), which activates PPARα, PPARδ and PPARγ with EC₅₀s of 0.7, 0.7 and 1.8 μM, respectively. PPAR agonist 4 exhibits anti-liver fibrosis efficacy .

HY-14922

Fosalvudine tidoxil	Reverse Transcriptase HIV	Infection
Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Fosalvudine tidoxil is a prodrug derived from Alovudine (HY-B1516). Fosalvudine tidoxil is less toxic than Alovudine and can be used for the research of HIV-1 infection .

HY-116431

I-BOP	Prostaglandin Receptor	Cardiovascular Disease Neurological Disease
I-BOP is an agonist for thromboxane A2 receptor (TP) with a K_D of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle . I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons .

HY-14542A

Ziprasidone hydrochloride CP-88059 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist . Ziprasidone hydrochloride has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM) .

HY-P1025

M40	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-P4296

H-Gly-Sar-Sar-OH	Amino Acid Derivatives	Others
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation .

HY-131696

11-deoxy Prostaglandin F1α 11-deoxy PGF1α	Others	Cardiovascular Disease Others
11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor .

HY-P1025A

M40 TFA	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

HY-10716A

PF-03463275	GlyT	Neurological Disease
PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a K_i of 11.6 nM. PF-03463275 has the potential for Schizophrenia research .

HY-106093

Eltenac	COX	Inflammation/Immunology
Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood .

HY-107751

BW373U86

SNC86
Opioid Receptor Neurological Disease

BW373U86 (SNC86) is a δ-opioid receptor agonist with an IC₅₀ of 1.49 nM. BW373U86 shows antidepressant-like effects .

BW373U86 SNC86	Opioid Receptor	Neurological Disease
BW373U86 (SNC86) is a δ-opioid receptor agonist with an IC₅₀ of 1.49 nM. BW373U86 shows antidepressant-like effects .

HY-W012977

3,3-Dimethyl-1-butanol DMB; Neohexanol	TGF-beta/Smad NF-κB Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

HY-110221

Rp-8-pCPT-cGMPS sodium	PKG	Neurological Disease
Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner .

HY-106968

ZD-9379	iGluR	Neurological Disease
ZD-9379 is a potent, orally active, and brain penetrant full antagonist at the glycine site of the NMDA receptor. ZD-9379 has neuroprotective effect .

HY-105266

Zabicipril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Zabicipril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Zabicipril can be used for the study of blood pressure and peripheral arterial insufficiency .

HY-113608

VCP171	Adenosine Receptor	Neurological Disease
VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain .

HY-123298

Chrysotoxine	Src Akt Apoptosis	Cancer
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research .

HY-149179

Polymyxin B 2 Publications Verification	Bacterial Antibiotic	Infection
Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research .

HY-B1232

Metyrapone 5 Publications Verification Su-4885	Endogenous Metabolite Cytochrome P450 Autophagy	Neurological Disease Metabolic Disease Endocrinology Cancer
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

HY-144627

PROTAC Axl Degrader 2	PROTACs TAM Receptor	Cancer
PROTAC Axl Degrader 2 is a potent and selective PROTAC Axl degrader with an IC₅₀ of 1.61 µM. PROTAC Axl Degrader 2 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 2 induces mehuosis .

HY-144624

PROTAC Axl Degrader 1	PROTACs TAM Receptor	Cancer
PROTAC Axl Degrader 1 is a potent and selective PROTAC Axl degrader with an IC₅₀ of 0.92 µM. PROTAC Axl Degrader 1 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 1 induces mehuosis .

HY-B1232A

Metyrapone Tartrate Su-4885 Tartrate	Endogenous Metabolite Cytochrome P450 Autophagy mTOR	Neurological Disease Endocrinology
Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression .

HY-155406

Estrogen receptor modulator 10	Estrogen Receptor/ERR Caspase Bcl-2 Family	Cancer
Estrogen receptor modulator 10 (compound G-5b) is an Estrogen receptor (ER) antagonist (IC₅₀=6.7 nM) and degrader (DC₅₀=0.4 nM). Estrogen receptor modulator 10 can induce apoptosis. Estrogen receptor modulator 10 can block cells at the G1/G0 phase. Estrogen receptor modulator 10 can be used in cancer studies .

HY-A0093

Mexiletine hydrochloride 1 Publications Verification KOE-1173 hydrochloride	Sodium Channel	Cardiovascular Disease Neurological Disease
Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC₅₀ : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .

HY-N0124

Dioscin Maximum Cited Publications 8 Publications Verification Collettiside III; CCRIS 4123	Autophagy Apoptosis	Cancer
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .

HY-B1019

Sulpiride 5 Publications Verification	Dopamine Receptor	Neurological Disease
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

M40 TFA	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

Big endothelin-1 (rat 1-39)	Peptides	Cardiovascular Disease
Big endothelin-1 (rat 1-39) is a 39-residues peptide. Big endothelin-1 (rat 1-39) induces diuretic and natriuretic response in conscious Sprague-Dawley rats. Big endothelin-1 (rat 1-39) raises blood pressure in mice .

DL-threo-3-Hydroxyaspartic acid	Peptides	Others
DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat .

M40	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease
M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .

H-Gly-Sar-Sar-OH	Amino Acid Derivatives	Others
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation .

3,3-Dimethyl-1-butanol DMB; Neohexanol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	TGF-beta/Smad NF-κB Endogenous Metabolite
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

Metyrapone 5 Publications Verification Su-4885	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Cancer	Endogenous Metabolite Cytochrome P450 Autophagy
Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .

(+)-Osbeckic acid	Polygonaceae Source classification Fagopyrum tataricum (L.) Gaertn. Plants	Others
(+)-Osbeckic acid is a vasorelaxatant that can be isolated from Tartary Buckwheat. (+)-Osbeckic acid has a potent vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings with an EC₅₀ of 887 μM .

Chrysotoxine	Structural Classification Monophenols Orchidaceae Source classification Phenols Plants Dendrobium pulchellum Roxb. et Lindl. :Lindl.	Src Akt Apoptosis
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research .

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