CK-963
Based on 1 Customer Validation
CK-963 is an activator for cardiac troponin (cTnC) with Ki of 11.5 μM. CK-963 exhibits activity in enhancing cardiac contractility in Sprague-Dawley rats.
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- Reinheit: 99.23%
- CAS. Nr.: 2851991-63-2
- Formel: C27H36N6O5S
- Molecular Weight:556.68
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Pharmacokinetic Analysis in SD rats Model[1]
| Route | Dose (mg/kg) | Solubility (μM) | CL (mL·min/kg) | T1/2 (h) | Vd (L/kg) | PPB (% unbound) |
| i.v. | 0.5 | 107.2 | 7.1 | 0.6 | 3.8 | 3.7 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2851991-63-2
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Appearance Solid
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Molecular Weight 556.68
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Formel C27H36N6O5S
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Color White to off-white
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SMILES
O=S(C(C=C(C(NC(C)=N1)=O)C1=C2)=C2OCCN3CCOCC3)(NC4=CC=C(N5C[C@H](C)C[C@@H](C)C5)N=C4)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (179.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7964 mL | 8.9818 mL | 17.9636 mL | 44.9091 mL |
| 5 mM | 0.3593 mL | 1.7964 mL | 3.5927 mL | 8.9818 mL | |
| 10 mM | 0.1796 mL | 0.8982 mL | 1.7964 mL | 4.4909 mL | |
| 15 mM | 0.1198 mL | 0.5988 mL | 1.1976 mL | 2.9939 mL | |
| 20 mM | 0.0898 mL | 0.4491 mL | 0.8982 mL | 2.2455 mL | |
| 25 mM | 0.0719 mL | 0.3593 mL | 0.7185 mL | 1.7964 mL | |
| 30 mM | 0.0599 mL | 0.2994 mL | 0.5988 mL | 1.4970 mL | |
| 40 mM | 0.0449 mL | 0.2245 mL | 0.4491 mL | 1.1227 mL | |
| 50 mM | 0.0359 mL | 0.1796 mL | 0.3593 mL | 0.8982 mL | |
| 60 mM | 0.0299 mL | 0.1497 mL | 0.2994 mL | 0.7485 mL | |
| 80 mM | 0.0225 mL | 0.1123 mL | 0.2245 mL | 0.5614 mL | |
| 100 mM | 0.0180 mL | 0.0898 mL | 0.1796 mL | 0.4491 mL |
CK-963 Related Classifications
HY-162345 Related Classifications
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